Drug development

MIT researchers have devised a new vaccine candidate for the Zika virus. “It functions almost like a synthetic virus, except it’s not pathogenic and it doesn’t spread,” says postdoc Omar Khan.

Progress toward a Zika vaccine

Researchers program RNA nanoparticles that could protect against the virus.

March 29, 2017

MIT researchers have designed a machine that can rapidly produce large quantities of customized peptides.

New technology offers fast peptide synthesis

Automated manufacturing could make it easier to develop and test new peptide drugs.

February 27, 2017

MIT professors Richard Braatz, J. Christopher Love, and Kripa Varanasi (pictured l-r) will collaborate with partners from University College London, and the University of Kansas to develop a next-generation manufacturing platform to produce certain vaccines for less than 15 cents a dose.

MIT undertakes Grand Challenge for innovation in global vaccine manufacturing

Bill and Melinda Gates Foundation awards MIT, University College London, and University of Kansas $17.6M for development and production of low-cost vaccines.

February 22, 2017

Coming together for immuno-oncology

Takeda's $1 million gift to the MIT Koch Institute will advance research into how the immune system affects cancer.

February 13, 2017

MIT spinout Manus Bio has created a low-cost process for engineering microbes with complex metabolic pathways borrowed from plants, which can produce an array of rare and expensive ingredients used to manufacture noncaloric beverages, perfumes, toothpastes, detergents, pesticides, and even therapeutics, among other products.

Microbial manufacturing

Engineered bacteria produce rare and commercially useful compounds in large quantities.

February 3, 2017

MIT and Boston College chemists have devised a way to attach fluorine-containing chemical groups to drug compounds, which could make the drugs more potent.

Catalyst adds fluorine-containing groups to make new compounds

Introducing such groups to potential drugs could make them more effective.

January 23, 2017

Barbara Imperiali, Class of 1922 Professor of Biology and professor of chemistry

Probing the function of key proteins

Professor Barbara Imperiali creates better biochemical tools for basic biology and drug development.

January 12, 2017

MIT spinout Benchling is bringing life science researchers a cloud-based platform that integrates different types of lab software into one place, with aims of making research and development easier, quicker, and more collaborative.

“Google Docs” for life sciences accelerates discovery

Cloud-based platform assists in managing, sharing data facilitates research.

December 7, 2016

Molecular fMRI data showing signal changes from serotonin sensors in the absence (left) and presence (right) of the antidepressant Prozac, with each square denoting an individual brain voxel. Red squares indicate the signal has increased, as more serotonin is absorbed into neurons; blue squares indicate the signal has decreased, as less serotonin is absorbed into neurons. Dotted and solid lines gr...

Mapping serotonin dynamics in the living brain

Imaging technique that creates 3-D video of serotonin transport could aid antidepressant development.

October 20, 2016

3Q: Berhardt Trout on spurring innovation in drug manufacturing

From EpiPen pricing to government oversight, the making of medicine impacts all aspects of modern health care.

September 23, 2016

Researchers at MIT and other institutions have created tiny freeze-dried pellets that include all of the molecular machinery needed to translate DNA into proteins, which could form the basis for on-demand production of drugs and vaccines.

To produce biopharmaceuticals on demand, just add water

Freeze-dried cellular components can be rehydrated to churn out useful proteins.

September 22, 2016

A team of MIT scientists has developed a strategy for delivering large numbers of beneficial bacterial to the human gut. The strategy involves coating bacteria with polymer layers that protect them from the acids and bile salts found in the digestive tract.

Delivering beneficial bacteria to the GI tract

Method that transports microbes through the stomach to the intestine may benefit human health.

September 14, 2016

A new technique invented at MIT can precisely measure the growth of many individual cells simultaneously. “The device provides new insights into how cells grow and respond to drugs,” MIT professor Scott Manalis says.

Microchip enables fast, precise measurement of single-cell growth

Device that measures growth of many individual cells simultaneously could lead to rapid tests for antibiotics.

September 5, 2016

Researchers at MIT have for the first time identified the structure of class I fumarate hydratase enzyme, which could be a target for drugs combatting diseases prevalent in the developing world.

Targeting neglected diseases

New enzyme-mapping advance could help drug development.

August 15, 2016

A research team led by MIT chemistry professor Mohammad Movassaghi has developed a strategy for synthesizing a group of compounds called communesins, which occur naturally in some fungi. Researchers may now be able to further investigate the compounds’ cancer-fighting abilities. Pictured is an image of penicillium fungus.

A new approach to chemical synthesis

Communesins, originally found in fungus, could hold potential as cancer drugs.

June 7, 2016

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