Cancer

Researchers at MIT and MGH have developed an image-guided surgical system that could help surgeons better visualize and remove tiny ovarian tumors. Fluorescent carbon nanotubes are used as probes to bind to the tumors, making them easier to see.

Imaging system helps surgeons remove tiny ovarian tumors

More effective surgery could boost survival rates for ovarian cancer.

April 23, 2019

Pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red). By growing cancer cells in the lab, researchers can study factors that promote and prevent the formation of deadly tumors.

The fluid that feeds tumor cells

The substance that bathes tumors in the body is quite different from the medium used to grow cancer cells in the lab, biologists report.

April 16, 2019

A group of academic institutions has granted a license for SHERLOCK, the highly-sensitive, low-cost CRISPR-based diagnostic, for commercial uses in the developed world, while reserving rights to enable its broad use by organizations to serve developing nations as well as unmet public health needs in the developed world.

Academic institutions grant commercial license for CRISPR-based SHERLOCK diagnostic technology in developed world

Rights are protected for broad use in developing world and for public health needs.

March 21, 2019

In these tumor cells, acidic regions are labeled in red. Invasive regions of the cells, which express a protein called MMP14, are labeled in green.

How tumors behave on acid

Acidic environment triggers genes that help cancer cells metastasize.

March 20, 2019

Using machine learning for medical solutions

Master’s student and Marshall Scholar Kyle Swanson uses computer science to help make drug development more efficient.

March 19, 2019

MIT researchers have discovered a way to manipulate the interactions of the proteins Myc and Max, which regulate gene transcription. At left, Myc interacts with Max, at center, Max is alone, at right, two molecules of Max.

A new approach to drugging a difficult cancer target

Study suggests an alternative way to treat tumors that are dependent on the cancer-promoting Myc protein.

March 14, 2019

MIT researchers have devised a way to simultaneously image in multiple wavelengths of near-infrared light, allowing them to determine the depth of particles emitting different wavelengths.

New optical imaging system could be deployed to find tiny tumors

Near-infrared technology pinpoints fluorescent probes deep within living tissue; may be used to detect cancer earlier.

March 7, 2019

The binding interface between a peptide and its Bcl-2 protein target is composed of common structural motifs known as TERMs.

Predicting sequence from structure

Researchers have devised a faster, more efficient way to design custom peptides and perturb protein-protein interactions.

February 15, 2019

At left, photoreceptor cells of the retina have undergone severe damage after treatment with an alkylating agent. This damage is exacerbated by the DNA repair enzyme Aag. At right, photoreceptor cells lacking Aag appear normal following treatment with the alkylating agent.

Why too much DNA repair can injure tissue

Overactive repair system promotes cell death following DNA damage by certain toxins, study shows.

February 12, 2019

MIT biological engineers have developed a way to rapidly measure cell survival rates by growing many cell colonies and imaging their fluorescently labeled DNA.

A better way to measure cell survival

New test rapidly evaluates the effect of drugs and potentially toxic compounds on cells.

February 5, 2019

MIT researchers found that lung tumors in mice treated with antibiotics (right, purple stain) were much smaller than untreated lung tumors (left).

Bacteria promote lung tumor development, study suggests

Antibiotics or anti-inflammatory drugs may help combat lung cancer.

January 31, 2019

MIT researchers’ new platform detects and extracts rare circulating tumor cells from live mouse models using a combination of laser excitation and a microfluidic chip.

From microfluidics to metastasis

New platform enables longitudinal studies of circulating tumor cells in mouse models of cancer.

January 21, 2019

MIT researchers have 3-D printed a novel microfluidic device that simulates cancer treatments on biopsied tumor tissue — and keeps the tissue alive for days — so clinicians can better examine how individual patients will respond to different therapeutics.

To guide cancer therapy, device quickly tests drugs on tumor tissue

Inexpensive 3-D-printed microfluidics device could be used to personalize cancer treatment.

December 12, 2018

MIT researchers are developing ribonucleases as potential drugs to treat cancer. In a new study, they found that the drugs work better when given with already-approved drugs known as kinase inhibitors.

New drug combination could be more effective against melanoma

Chemists discover an unexpected synergy between two types of cancer drugs.

December 3, 2018

An enzyme encircles the double helix to repair a broken strand of DNA.

The long and short of CDK12

A new study linking RNA processing to DNA repair may open new avenues to cancer therapy.

November 30, 2018

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