Memory

Three brain regions collaborate to produce working memory, but when it reaches capacity, their synchrony breaks down.

A heavy working memory load may sink brainwave 'synch'

Picower Institute study explains what happens when working memory reaches its full capacity.

April 6, 2018

This image shows neurons in the CA3 region of the hippocampus, which is important for memory encoding and retrieval. Nuclei of the CA3 neurons are labeled in green and their dendrites in red, and the smaller specks of green above represent axons projecting to the CA3 neurons from the dentate gyrus.

Study reveals molecular mechanisms of memory formation

Neuroscientists discover a cellular pathway that encodes memories by strengthening specific synapses.

February 8, 2018

Our daily lives include hundreds of routine habits, made up of many smaller actions, such as picking up our toothbrush, squeezing toothpaste onto it, and then lifting the brush to our mouth. This process of grouping behaviors together into a single routine is known as “chunking.” MIT neuroscientists have now found that certain neurons in the brain are responsible for marking the beginning and ...

Distinctive brain pattern helps habits form

Study identifies neurons that fire at the beginning and end of a behavior as it becomes a habit.

February 8, 2018

MIT neuroscientists have found evidence that the brain’s ability to control what it’s thinking about relies on low-frequency brain waves known as beta rhythms.

New study reveals how brain waves control working memory

Brain rhythms act as a gate for information entering and leaving the mind.

January 26, 2018

Study: Rhythmic interactions between cortical layers underlie working memory

MIT neuroscientists suggest a model for how we gain volitional control of what we hold in our minds.

January 15, 2018

The image shows the locus coeruleus, which drives neuronal circuits of the hippocampus and enables novel contextual memory. The red staining shows norepinephrine transporter (NET)-positive cells, indicating the locus coeruleus. The green staining shows adeno-associated virus (AAV)-mediated expressions of light-sensitive inhibitory opsin, archaerhodopsin (Arch). The blue staining shows all cells in...

How the brain selectively remembers new places

Neuroscientists identify a circuit that helps the brain record memories of new locations.

December 25, 2017

A nutrient mix based in part on research from the lab of MIT Professor Emeritus Richard Wurtman has shown promise in treating the early stages of Alzheimer’s disease.

MIT research laid groundwork for promising Alzheimer’s-fighting drink

Studies by Richard Wurtman have led to development of nutrient mix shown to slow cognitive impairment in early stages of the disease.

October 30, 2017

The green staining shows hippocampal CA1 engram cells, which store a long-term fear memory and have the light sensitive optogenetic protein channelrhodopsin-2. The blue staining shows all cells in the dorsal hippocampus brain region, including non-engram cells (blue color staining only).

MIT neuroscientists build case for new theory of memory formation

Existence of “silent engrams” suggests that existing models of memory formation should be revised.

October 23, 2017

Microglia, the brain's immune cells, scavenge the brain for repairs and to remove potential infectious agents.

Cellular reprograming implicated in model of Alzheimer's disease

Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer's disease.

October 12, 2017

Brain waves reflect different types of learning

For the first time, researchers have identified neural signatures of explicit and implicit learning.

October 11, 2017

MIT engineers have devised a way to automate the process of monitoring neurons in a living brain using a computer algorithm that analyzes microscope images and guides a robotic arm to the target cell. In this image, a pipette guided by a robotic arm approaches a neuron identified with a fluorescent stain.

Robotic system monitors specific neurons

Success rate is comparable to that of highly trained scientists performing the process manually.

August 30, 2017

MIT neuroscientists have shown, for the first time, that recalling a memory requires a “detour” circuit that branches off from the original memory circuit. This low-magnification image shows that hippocampal CA1 neurons (red) and dorsal subiculum neurons (green) can be genetically identified using two different protein markers.

How we recall the past

Neuroscientists discover a brain circuit dedicated to retrieving memories.

August 17, 2017

An MIT study of the neural circuits that underlie memory process reveals, for the first time, that memories are formed simultaneously in the hippocampus and the long-term storage location in the brain’s cortex. This image shows memory engram cells (green and red) which are crucial for permanent memory storage in the prefrontal cortex.

Neuroscientists identify brain circuit necessary for memory formation

New findings challenge standard model of memory consolidation.

April 6, 2017

MIT Assistant Professor Kay Tye (left) receives the Young Investigator Award from Society for Neuroscience President Hollis Cline.

Kay Tye Receives the Society for Neuroscience Young Investigator Award

Picower Neuroscientist recognized for her work on emotional circuitry of the brain.

November 15, 2016

Beta-amyloid plaque deposits (red) disrupt mylelin (green) organization in the brain and activate microglia (orange), driving the inflammation, neurodegeneration, and cognitive disfunction associated with Alzheimer's disease.

Creating therapies for Alzheimer's disease by targeting neural circuits

Study finds a complex series of molecular, cellular, circuit and network-level changes contribute to the progression of Alzheimer's.

November 9, 2016

MIT News | Massachusetts Institute of Technology

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