An on-off switch for gene editing
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.
Basic cell health systems wear down in Huntington’s disease, analysis shows
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.
A high-resolution glimpse of gene expression in cells
Expanding tissue samples before sequencing allows researchers to pinpoint locations of RNA molecules.
Scientists seek insight into Parkinson’s, addiction by tracking gene expression in the brain
Two MIT faculty members earn funding from the G. Harold and Leila Y. Mathers Foundation.
RNA molecules are masters of their own destiny
Research suggests the products of transcription — RNA molecules — regulate their own production through a feedback loop.
3 Questions: Phillip Sharp on the discoveries that enabled mRNA vaccines for Covid-19
Curiosity-driven basic science in the 1970s laid the groundwork for today’s leading vaccines against the novel coronavirus.
Explained: Why RNA vaccines for Covid-19 raced to the front of the pack
Many years of research have enabled scientists to quickly synthesize RNA vaccines and deliver them inside cells.
Regulating the regulators
Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.
Silencing gene expression to cure complex diseases
Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.
Nanoparticles can turn off genes in bone marrow cells
Using these new particles, researchers could develop treatments for heart disease and other conditions.
Scientists discover new rules about “runaway” transcription
Findings related to bacterial gene expression overturn fundamental assumptions about basic biological pathways.
Bringing RNA into genomics
ENCODE consortium identifies RNA sequences that are involved in regulating gene expression.
Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA
Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.
SMART researchers receive grant to develop rapid tests for Covid-19
Using engineered binder proteins to detect viral proteins or antibodies rather than RNA, new tests may overcome current challenges in testing for SARS-CoV-2 virus.
Nature-inspired CRISPR enzymes for expansive genome editing
Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.