Biologist Joey Davis explores how cells build complex structures
His studies have shed light on the assembly instructions that govern ribosomes, the critical protein-building machines of the cell.
Study: Gene circuits reshape DNA folding and affect how genes are expressed
When genes are transcribed, they suppress or activate their neighbors, coupling expression between the two genes.
Study reveals “two-factor authentication” system that controls microRNA destruction
Researchers uncovered how cells selectively destroy certain microRNAs — key gene regulators — through a mechanism that requires two RNA signals working together.
Scientists discover genetics behind leaky brain blood vessels in Rett syndrome
By showing the problem derives from genetic mutations that lead to overexpression of a microRNA, MIT researchers’ study points to potential treatment.
Studying the genetic basis of disease to explore fundamental biological questions
Eliezer Calo’s studies of craniofacial malformations have yielded insight into protein synthesis and embryonic development.
New insights into a hidden process that protects cells from harmful mutations
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
Designing the future of metabolic health through tissue-selective drug delivery
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
Celebrating worm science
Time and again, an unassuming roundworm has illuminated aspects of biology with major consequences for human health.
New study suggests a way to rejuvenate the immune system
Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination.
RNA editing study finds many ways for neurons to diversify
Tracking how fruit fly motor neurons edit their RNA, neurobiologists cataloged hundreds of target sites and varying editing rates, finding many edits altered communication- and function-related proteins.
MIT researchers find new immunotherapeutic targets for glioblastoma
A study profiling antigens presented on immune and tumor cells in co-culture points to new strategies for attacking a treatment-resistant and deadly brain cancer.
MIT study finds targets for a new tuberculosis vaccine
Using these antigens, researchers plan to develop vaccine candidates that they hope would stimulate a strong immune response against the world’s deadliest pathogen.
A new way to understand and predict gene splicing
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.
Turning on an immune pathway in tumors could lead to their destruction
MIT researchers show they can use messenger RNA to activate the pathway and trigger the immune system to attack tumors.
New RNA tool to advance cancer and infectious disease research and treatment
Advance from SMART will help to better identify disease markers and develop targeted therapies and personalized treatment for diseases such as cancer and antibiotic-resistant infection.