Speeding up drug discovery for brain diseases
Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.
Translating proteins into music, and back
By turning molecular structures into sounds, researchers gain insight into protein structures and create new variations.
A “biomultimeter” lets scientists measure RNA and protein production in real-time
Fluorescent tagging system can expedite the process of designing genes and personalizing medicine.
Predicting sequence from structure
Researchers have devised a faster, more efficient way to design custom peptides and perturb protein-protein interactions.
Enhanced NMR reveals chemical structures in a fraction of the time
Technique could yield insights into complex proteins involved in Alzheimer’s and other diseases.
Protein has unique effects on information processing
Picower Institute researchers find that a key protein linked to intellectual disability shapes electrical currents in neural connections.
Scientists alter membrane proteins to make them easier to study
By making hydrophobic sections water-soluble, researchers hope to learn more about protein structures.
Researchers decode molecule that gives living tissues their flexibility
Study reveals atomic structure of tropoelastin, showing what goes wrong in some diseases.
Structure of key growth regulator revealed
Researchers identify the molecular structure of the GATOR1 protein complex, which regulates growth signals in human cells, using cryo-electron microscopy.
New sensors can detect single protein molecules
Modified carbon nanotubes could be used to track protein production by individual cells.
Probing the function of key proteins
Professor Barbara Imperiali creates better biochemical tools for basic biology and drug development.
Protein imaging reveals detailed brain architecture
New technique could contribute to efforts to map the human brain.
Engineers design magnetic cell sensors
New protein nanoparticles allow scientists to track cells and interactions within them.
Analyzing protein structures in their native environment
Enhanced-sensitivity NMR could reveal new clues to how proteins fold.
Automating single-molecule image studies
MIT physics graduate student James Owen Andrews is developing software to improve dynamic image capture from super-resolution fluorescent microscopes.