Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.
Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.
Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.
By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.
With SHERLOCK, a strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest.
“REPAIR” system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome.
MIT associate professor and member of the Broad Institute and McGovern Institute recognized for commitment to invention, collaboration, and mentorship.
New system adapts tool known for gene editing; to be used in rapid, inexpensive disease diagnosis.