MIT scientists discover new antiviral defense system in bacteria
Prokaryotes can detect hallmark viral proteins and trigger cell death through a process seen across all domains of life.
New CRISPR-based map ties every human gene to its function
Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.
Convenience-sized RNA editing
MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.
Using plant biology to address climate change
A Climate Grand Challenges flagship project aims to reduce agriculture-driven emissions while making food crop plants heartier and more nutritious.
Volta Labs: Improving workflows for genetic applications
Udayan Umapathi SM ’17 and Will Langford SM ’14, PhD ’19 are co-founders of a Media Lab spinoff building a full-stack platform to enable automation for genomics and genetic engineering.
RNA-targeting enzyme expands the CRISPR toolkit
Exploring diversity among bacterial immune systems, McGovern Institute scientists uncovere a programmable system for precisely targeting and modifying RNA.
New programmable gene editing proteins found outside of CRISPR systems
Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.
Scientists harness human protein to deliver molecular medicines to cells
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.
A new technique for correcting disease-causing mutations
Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.
Nature-inspired CRISPR enzymes for expansive genome editing
Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.
Using gene editing, neuroscientists develop a new model for autism
By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.
New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
Scientists engineer new CRISPR platform for DNA targeting
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
New CRISPR tool opens up more of the genome for editing
Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.
Researchers advance CRISPR-based tool for diagnosing disease
With SHERLOCK, a strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest.