New programmable gene editing proteins found outside of CRISPR systems
Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.
Scientists harness human protein to deliver molecular medicines to cells
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.
A new technique for correcting disease-causing mutations
Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.
Nature-inspired CRISPR enzymes for expansive genome editing
Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.
Using gene editing, neuroscientists develop a new model for autism
By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.
New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
Scientists engineer new CRISPR platform for DNA targeting
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
New CRISPR tool opens up more of the genome for editing
Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.
Researchers advance CRISPR-based tool for diagnosing disease
With SHERLOCK, a strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest.
Reading and writing DNA
Department of Biology kicks off IAP seminar series with a lecture by synthetic-biology visionary George Church.
Researchers engineer CRISPR to edit single RNA letters in human cells
“REPAIR” system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome.
Gene-editing technology developer Feng Zhang awarded $500,000 Lemelson-MIT Prize
MIT associate professor and member of the Broad Institute and McGovern Institute recognized for commitment to invention, collaboration, and mentorship.
Feng Zhang to share Albany Medical Prize
Five recipients honored for their fundamental and complementary accomplishments related to CRISPR-Cas9.
Scientists unveil CRISPR-based diagnostic platform
New system adapts tool known for gene editing; to be used in rapid, inexpensive disease diagnosis.
3Q: Behind the scenes of the National Academy of Sciences' report on human genome editing
MIT professor and NAS report committee co-chair Richard Hynes gives insight into the report’s recommendations.