Brain and cognitive sciences

MIT neuroscientists have linked the vulnerability of neurons in Hungtington's disease to the release of mitochondrial RNA and an associated immune system response. In this image, on the right are neurons from a Huntington's model mouse showing much more PKR (a marker of immune response to mitochondrial RNA) in green than neurons on the left, which are from a healthy mouse.

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

July 21, 2020

The left side shows a "tonic" neuron (stained green) growing to just one muscle on the right of the panel. In the next panel, one can see a "phasic" neuron (also stained green) connecting to more than one muscle.

Seemingly similar, two neurons show distinct styles as they interact with the same muscle partner

Diversity in how cells talk to the muscle they innervate reveal distinct propensities for change, or “plasticity.”

July 20, 2020

Within a microscope image of neurons from the hippocampus region of a rodent brain (left), a zoomed-in section (red square) of a neuron's dendrites shows spines (right) where many synaptic connections with other neurons reside.

Findings weaken notion that size equals strength for neural connections

Among study’s many surprises may be a new way to address Fragile X syndrome — by finding a “protein X.”

July 14, 2020

LEAH Knox program instructor Vanessa Cheung teaches lab techniques remotely.

LEAH Knox Scholars Program kicks off fourth summer

The science program for local high school students is remote this year, as MIT instructors create at-home lab experiences.

July 14, 2020

3D renderings of simulated multi-bolus delivery to various brain structures (striatum, amygdala, substantia nigra, and hippocampus) show one to four boluses.

COMMANDing drug delivery

A new computational method fine-tunes delivery of therapeutics to specific brain regions.

July 10, 2020

Newly tenured MIT science professors include: (top row, l-r) Ibrahim Cissé, Mehrdad Jazayeri, Lindley Winslow; (middle row, l-r) Adam Willard, Yogesh Surendranath, Mark Vogelsberger; (bottom row, l-r) Joshua McDermott, Jörn Dunkel, Yen-Jie Lee.

Nine MIT School of Science professors receive tenure for 2020

Professors earn tenure in the departments of Brain and Cognitive Sciences, Chemistry, Mathematics, and Physics.

July 7, 2020

Through research trips to the remote Bolivian rainforest, researchers in the McDermott lab at the McGovern Institute for Brain Research has found that aspects of the perception of note combinations may be universal.

Universal musical harmony

Acoustic and biological constraints shape how we hear harmony across cultures.

July 1, 2020

Using a new kind of microscope that closely tracks every movement, researchers seeking to study how organisms coordinate movement behaviors compiled a compendium of 100 reference postures that encompass the range of typical C. elegans poses.

How worms move: Dopamine helps nematodes coordinate motor behaviors

To spy on worms for days on end, Picower Institute scientists invent a new open-source microscopy platform.

June 30, 2020

Photo shows the device the team developed. The tube at top is connected to a supply of the precursor material, sodium nitrite, which then passes through a channel in the fiber at the bottom and into the body, which also contains the electrodes to stimulate the release of nitric oxide. The electrodes are connected through the four-pin connector on the left.

Producing a gaseous messenger molecule inside the body, on demand

Method could shed light on nitric oxide’s role in the neural, circulatory, and immune systems.

June 29, 2020

Using a new calcium indicator that accumulates in the cell bodies of neurons (boxes at right), MIT neuroscientists are able to more accurately image neuron activity. Traditional calcium indicators (boxes at left) can generate crosstalk that blurs the images.

A focused approach to imaging neural activity in the brain

New molecule for imaging calcium in neurons reduces crosstalk from neighboring neurons.

June 26, 2020

Researchers use skeletal keypoint data to match the movements of musicians with the tempo of their part, allowing listeners to isolate similar-sounding instruments.

Identifying a melody by studying a musician’s body language

Music gesture artificial intelligence tool developed at the MIT-IBM Watson AI Lab uses body movements to isolate the sounds of individual instruments.

June 25, 2020

When keeping track of location a particular region of the brain, the lateral septum, pays special attention to where the reward is located, compared to another region, the hippocampus, that tracks location without that same bias.

Like a treasure map, brain region emphasizes reward location

The lateral septum encodes spatial information with a special emphasis on where the reward lies.

June 23, 2020

Researchers present at the MIT-Takeda launch event earlier this year.

MIT-Takeda program launches

Research projects will harness the power of artificial intelligence to positively impact human health.

June 18, 2020

An MIT-led research team has discovered evidence that a classic visual illusion called simultaneous brightness contrast, such as the one seen here, relies on brightness estimation that takes place in the retina, not the brain’s visual cortex. In this image, the two small discs appear to have different brightness despite having identical luminance.

Study sheds light on a classic visual illusion

Neuroscientists delve into how background brightness influences our perception of an object.

June 16, 2020

In Alzheimer's disease, the blood-brain barrier can become disrupted by the accumulation of amyloid protein, especially in people who carry a genetic variant called APOE4. This 3D rendering of an APOE4-carrying engineered blood vessel shows heavy accumulation of amyloid protein (green).

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

MIT researchers pinpoint mechanism and demonstrate that drugs could help.

June 15, 2020

MIT News | Massachusetts Institute of Technology

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