New method allows scientists to follow gene activity over time in the same cells
In the new method, cells package and export their RNA, enabling researchers to sequence and analyze the RNA without killing the cells.
Giving farmers a more sustainable way to protect crops
Led by Andee Wallace PhD ’20, Robigo uses cutting-edge biotechnology to engineer microbes to fight pests, reducing the need for harmful chemical pesticides.
Cells use a little-known molecule to protect themselves from iron overload
This discovery points toward new combination strategies against cancer, and may explain the iron buildup seen in disorders such as early-onset Parkinson’s disease.
Flipping the script on biology education, and scaling it up
Using a modular kit, the MIT Edgerton Center is bringing a hands-on biology curriculum to Massachusetts’ second-largest school district.
Why are some bacterial genes high in purines?
In certain species of bacteria, the answer lies in shielding RNA transcripts from a quality-control factor called Rho. Understanding the requirements for expressible sequences is critical for expression engineering of therapeutic agents.
A new approach to cancer vaccination yields more powerful T cells
Using immune-remodeling mRNA molecules, researchers generated T cells that can slow tumor growth and, in some cases, eradicate tumors.
Biologist Joey Davis explores how cells build complex structures
His studies have shed light on the assembly instructions that govern ribosomes, the critical protein-building machines of the cell.
Study: Gene circuits reshape DNA folding and affect how genes are expressed
When genes are transcribed, they suppress or activate their neighbors, coupling expression between the two genes.
Study reveals “two-factor authentication” system that controls microRNA destruction
Researchers uncovered how cells selectively destroy certain microRNAs — key gene regulators — through a mechanism that requires two RNA signals working together.
Scientists discover genetics behind leaky brain blood vessels in Rett syndrome
By showing the problem derives from genetic mutations that lead to overexpression of a microRNA, MIT researchers’ study points to potential treatment.
Studying the genetic basis of disease to explore fundamental biological questions
Eliezer Calo’s studies of craniofacial malformations have yielded insight into protein synthesis and embryonic development.
New insights into a hidden process that protects cells from harmful mutations
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
Designing the future of metabolic health through tissue-selective drug delivery
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
Celebrating worm science
Time and again, an unassuming roundworm has illuminated aspects of biology with major consequences for human health.
New study suggests a way to rejuvenate the immune system
Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination.