In certain species of bacteria, the answer lies in shielding RNA transcripts from a quality-control factor called Rho. Understanding the requirements for expressible sequences is critical for expression engineering of therapeutic agents.
Using immune-remodeling mRNA molecules, researchers generated T cells that can slow tumor growth and, in some cases, eradicate tumors.
His studies have shed light on the assembly instructions that govern ribosomes, the critical protein-building machines of the cell.
When genes are transcribed, they suppress or activate their neighbors, coupling expression between the two genes.
Researchers uncovered how cells selectively destroy certain microRNAs — key gene regulators — through a mechanism that requires two RNA signals working together.
By showing the problem derives from genetic mutations that lead to overexpression of a microRNA, MIT researchers’ study points to potential treatment.
Eliezer Calo’s studies of craniofacial malformations have yielded insight into protein synthesis and embryonic development.
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
Time and again, an unassuming roundworm has illuminated aspects of biology with major consequences for human health.
Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination.
Tracking how fruit fly motor neurons edit their RNA, neurobiologists cataloged hundreds of target sites and varying editing rates, finding many edits altered communication- and function-related proteins.
A study profiling antigens presented on immune and tumor cells in co-culture points to new strategies for attacking a treatment-resistant and deadly brain cancer.
Using these antigens, researchers plan to develop vaccine candidates that they hope would stimulate a strong immune response against the world’s deadliest pathogen.
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.