Scientists discover genetics behind leaky brain blood vessels in Rett syndrome
By showing the problem derives from genetic mutations that lead to overexpression of a microRNA, MIT researchers’ study points to potential treatment.
Studying the genetic basis of disease to explore fundamental biological questions
Eliezer Calo’s studies of craniofacial malformations have yielded insight into protein synthesis and embryonic development.
New insights into a hidden process that protects cells from harmful mutations
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
Designing the future of metabolic health through tissue-selective drug delivery
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
Celebrating worm science
Time and again, an unassuming roundworm has illuminated aspects of biology with major consequences for human health.
New study suggests a way to rejuvenate the immune system
Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination.
RNA editing study finds many ways for neurons to diversify
Tracking how fruit fly motor neurons edit their RNA, neurobiologists cataloged hundreds of target sites and varying editing rates, finding many edits altered communication- and function-related proteins.
MIT researchers find new immunotherapeutic targets for glioblastoma
A study profiling antigens presented on immune and tumor cells in co-culture points to new strategies for attacking a treatment-resistant and deadly brain cancer.
MIT study finds targets for a new tuberculosis vaccine
Using these antigens, researchers plan to develop vaccine candidates that they hope would stimulate a strong immune response against the world’s deadliest pathogen.
A new way to understand and predict gene splicing
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.
Turning on an immune pathway in tumors could lead to their destruction
MIT researchers show they can use messenger RNA to activate the pathway and trigger the immune system to attack tumors.
New RNA tool to advance cancer and infectious disease research and treatment
Advance from SMART will help to better identify disease markers and develop targeted therapies and personalized treatment for diseases such as cancer and antibiotic-resistant infection.
Remembering David Baltimore, influential biologist and founding director of the Whitehead Institute
The longtime MIT professor and Nobel laureate was a globally respected researcher, academic leader, and science policy visionary who guided the careers of generations of scientists.
Locally produced proteins help mitochondria function
Researchers developed an approach to study where proteins get made, and characterized proteins produced near mitochondria, gaining potential insights into mitochondrial function and disease.
How AI could speed the development of RNA vaccines and other RNA therapies
MIT engineers used a machine-learning model to design nanoparticles that can deliver RNA to cells more efficiently.