3 Questions: Lindsay Case on how cells organize and sense the world
Case’s new lab investigates why cancer arises when disruptions in cellular organization change how cells sense mechanical forces.
Truncated immune system receptors may regulate cellular activity
Unexpected findings in chemokine receptors once believed to be non-functional open up new fields of scientific inquiry.
Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help
Astrocytes with the APOE4 gene variant show deficits of a key cellular function, but overexpressing the gene PICALM overcame the defect.
New technology enables fast protein synthesis
Automated tabletop machine could accelerate the development of novel drugs to treat cancer and other diseases.
SMART researchers receive grant to develop rapid tests for Covid-19
Using engineered binder proteins to detect viral proteins or antibodies rather than RNA, new tests may overcome current challenges in testing for SARS-CoV-2 virus.
Study finds “volume dial” for turning neural communication up or down
The protein Synaptotagmin 7 limits supply of neurotransmitter-containing vesicles for release at synapses.
3 Questions: Hadley Sikes on searching for a Covid-19 protein test
Chemical engineer aims to create a test that can work in 10 minutes and doesn’t require specialized instruments or laboratory infrastructure.
Q&A: Markus Buehler on setting coronavirus and AI-inspired proteins to music
Translated into sound, SARS-CoV-2 tricks our ear in the same way the virus tricks our cells.
Biologists build proteins that avoid crosstalk with existing molecules
Engineered signaling pathways could offer a new way to build synthetic biology circuits.
Understanding genetic circuits and genome organization
Assistant professors Pulin Li and Seychelle Vos are investigating how cells become tissues and the proteins that organize DNA.
Cleaning up hydrogen peroxide production
Solugen’s engineered enzymes offer a biologically-inspired method for producing the chemical.
Characterizing tau aggregates in neurodegenerative diseases
New research reveals a structural model for amyloid fibrils that could aid in future medicinal interventions for Alzheimer's, CTE, and more.
How brain cells pick which connections to keep
Novel study shows protein CPG15 acts as a molecular proxy of experience to mark synapses for stabilization.
Speeding up drug discovery for brain diseases
Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.
Translating proteins into music, and back
By turning molecular structures into sounds, researchers gain insight into protein structures and create new variations.