Seeing more in expansion microscopy
New methods light up lipid membranes and let researchers see sets of proteins inside cells with high resolution.
An ancient RNA-guided system could simplify delivery of gene editing therapies
The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.
AI system predicts protein fragments that can bind to or inhibit a target
FragFold, developed by MIT Biology researchers, is a computational method with potential for impact on biological research and therapeutic applications.
AI model deciphers the code in proteins that tells them where to go
Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease.
MIT method enables ultrafast protein labeling of tens of millions of densely packed cells
Tissue processing advance can label proteins at the level of individual cells across large samples just as fast and uniformly as in dissociated single cells.
Cellular traffic congestion in chronic diseases suggests new therapeutic targets
Chronic diseases like diabetes are prevalent, costly, and challenging to treat. A common denominator driving them may be a promising new therapeutic target.
Creating the crossroads
Through academia and industry, Gevorg Grigoryan PhD ’07 says there is no right path — just the path that works for you.
CHARMed collaboration creates a potent therapy candidate for fatal prion diseases
A new gene-silencing tool shows promise as a future therapy against prion diseases and paves the way for new approaches to treating disease.
Protein study could help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
“Rosetta Stone” of cell signaling could expedite precision cancer medicine
An atlas of human protein kinases enables scientists to map cell signaling pathways with unprecedented speed and detail.
A new computational technique could make it easier to engineer useful proteins
MIT researchers plan to search for proteins that could be used to measure electrical activity in the brain.
Exploring the cellular neighborhood
Software allows scientists to model shapeshifting proteins in native cellular environments.
How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice
Study finds stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of an Alzheimer’s protein.
Future science at the molecular level
Brad Pentelute and his lab compel the anthrax delivery system to deliver antibody and peptide variants into cells to treat cancer.
Study explains how part of the nucleolus evolved
A single protein can self-assemble to build the scaffold for a biomolecular condensate that makes up a key nucleolar compartment.