Future science at the molecular level
Brad Pentelute and his lab compel the anthrax delivery system to deliver antibody and peptide variants into cells to treat cancer.
Study explains how part of the nucleolus evolved
A single protein can self-assemble to build the scaffold for a biomolecular condensate that makes up a key nucleolar compartment.
New sensor mimics cell membrane functions
The device detects the same molecules that cell receptors do, and may enable routine early screening for cancers and other diseases.
Probe expands understanding of oral cavity homeostasis
A new approach opens the door to a greater understanding of protein-microbe interactions.
It takes three to tango: transcription factors bind DNA, protein, and RNA
Whitehead Institute researchers find many transcription factors bind RNA, which fine-tunes their regulation of gene expression, suggesting new therapeutic opportunities.
Scientists pinpoint where thousands of individual proteins are made in intact tissue and single cells
A new technology called RIBOmap can give researchers valuable insight into how protein production in animal and human tissue is altered in disease.
Generative AI imagines new protein structures
“FrameDiff” is a computational tool that uses generative AI to craft new protein structures, with the aim of accelerating drug development and improving gene therapy.
Chemists discover why photosynthetic light-harvesting is so efficient
The disorganized arrangement of the proteins in light-harvesting complexes is the key to their extreme efficiency.
Without a key extracellular protein, neuronal axons break and synaptic connections fall apart
Scientists find a protein common to flies and people is essential for supporting the structure of axons that neurons project to make circuit connections.
New model offers a way to speed up drug discovery
By applying a language model to protein-drug interactions, researchers can quickly screen large libraries of potential drug compounds.
Tiny diamond rotor could improve protein studies
A new way of machining microscale rotors from diamond crystal can enable ultrasensitive NMR devices for probing proteins and other materials.
AI system can generate novel proteins that meet structural design targets
These tunable proteins could be used to create new materials with specific mechanical properties, like toughness or flexibility.
Bacterial injection system delivers proteins in mice and human cells
With further development, the programmable system could be used in a range of applications including gene and cancer therapies.
New purification method could make protein drugs cheaper
MIT engineers find specialized nanoparticles can quickly and inexpensively isolate proteins from a bioreactor.
Self-assembling proteins can store cellular “memories”
Using these engineered proteins, researchers can record histories that reveal when certain genes are activated or how cells respond to a drug.