It takes three to tango: transcription factors bind DNA, protein, and RNA
Whitehead Institute researchers find many transcription factors bind RNA, which fine-tunes their regulation of gene expression, suggesting new therapeutic opportunities.
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.
With fractured genomes, Alzheimer’s neurons call for help
Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.
New CRISPR-based map ties every human gene to its function
Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.
Scientists seek insight into Parkinson’s, addiction by tracking gene expression in the brain
Two MIT faculty members earn funding from the G. Harold and Leila Y. Mathers Foundation.
Fast modeling of cancer mutations
New genome-editing technique enables rapid analysis of genes mutated in tumors.
Kellis to lead MIT team in new phase of GTEx project to elucidate basis of disease predisposition
NIH-sponsored work to characterize genetic variation in human tissues with roles in diabetes, heart disease, and cancer.
It’s in the genes — but whose?
Genetic material hitchhiking in our cells may shape physical traits more than we thought.
Research reveals structure of key CRISPR complex
Work reveals how a genome-editing tool works to correct errors in the genetic code.
Unusual suspects
Computer models plus observations of RNA inside a cell help scientists home in on a short list of interesting RNA ‘machines.’
Controlling genes with light
New technique can rapidly turn genes on and off, helping scientists better understand their function.
Research update: Genome editing becomes more accurate
Improved technique makes it easier to add or delete genes in living cells, with less risk of off-target DNA damage.
Reading DNA, backward and forward
MIT biologists reveal how cells control the direction in which the genome is read.