In a surprising discovery, scientists find tiny loops in the genomes of dividing cells
Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide.
A more precise way to edit the genome
MIT researchers have dramatically lowered the error rate of prime editing, a technique that holds potential for treating many genetic disorders.
This MIT spinout is taking biomolecule storage out of the freezer
Cache DNA has developed technologies that can preserve biomolecules at room temperature to make storing and transporting samples less expensive and more reliable.
Study finds cell memory can be more like a dimmer dial than an on/off switch
The findings may redefine how cell identity is established and enable the creation of more sophisticated engineered tissues.
Remembering David Baltimore, influential biologist and founding director of the Whitehead Institute
The longtime MIT professor and Nobel laureate was a globally respected researcher, academic leader, and science policy visionary who guided the careers of generations of scientists.
3 Questions: On biology and medicine’s “data revolution”
Professor Caroline Uhler discusses her work at the Schmidt Center, thorny problems in math, and the ongoing quest to understand some of the most complex interactions in biology.
A boost for the precision of genome editing
Researchers develop a fast-acting, cell-permeable protein system to control CRISPR-Cas9, reducing off-target effects and advancing gene therapy.
MIT engineers develop electrochemical sensors for cheap, disposable diagnostics
Electrodes coated with DNA could enable inexpensive tests with a long shelf-life, which could detect many diseases and be deployed in the doctor’s office or at home.
Rationale engineering generates a compact new tool for gene therapy
Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.
Scientists discover potential new targets for Alzheimer’s drugs
Pathways involved in DNA repair and other cellular functions could contribute to the development of Alzheimer’s.
With AI, researchers predict the location of virtually any protein within a human cell
Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.
Using AI to explore the 3D structure of the genome
Two meters of DNA is crammed into the nucleus of every human cell. Bin Zhang wants to know how gene expression works in this minuscule space.
Anders Sejr Hansen named Edgerton Award winner
MIT associate professor recognized for exceptional distinction in teaching, research, and service at MIT.
Restoring healthy gene expression with programmable therapeutics
CAMP4 Therapeutics is targeting regulatory RNA, whose role in gene expression was first described by co-founder and MIT Professor Richard Young.
At the core of problem-solving
Stuart Levine ’97, director of MIT’s BioMicro Center, keeps departmental researchers at the forefront of systems biology.