How well can computers connect symptoms to diseases?
Models that map these relationships based on patient data require fine-tuning for certain conditions, study shows.
Building a platform to image membrane proteins
Biologists devise an efficient method to prepare fluorescently tagged proteins and simulate their native environment.
A new way to regulate gene expression
Biologists uncover an evolutionary trick to control gene expression that reverses the flow of genetic information from RNA splicing back to transcription.
Tracking contagion in cities, using mobile phone data
Study shows how commuting and other forms of everyday travel help spread mosquito-borne disease in urban settings.
Ankur Jain awarded Packard Foundation Fellowship
Whitehead Institute member and assistant professor of biology receives one of the most prestigious non-governmental awards for early-career scientists.
Cell stiffness may indicate whether tumors will invade
Study shows tumors with softer, larger cells at their periphery are more likely to spread; may suggest new route for cancer therapy.
Alzheimer’s plaque emerges early and deep in the brain
Clumps of amyloid protein emerge early in deep regions, such as the mammillary body, and march outward in the brain along specific circuits.
Delivery system can make RNA vaccines more powerful
Vaccines packaged in novel nanoparticles could offer a new way to fight cancer and infectious diseases.
Uninfected patients key to improving Ebola response
New methodology may be used to respond to other endemic diseases.
A tech intervention to tame tuberculosis
An interactive program using mobile phones helps more patients conclude treatment successfully.
Ultrathin 3-D-printed films convert energy of one form into another
Low-cost “piezoelectric” films produce voltage, could be used for flexible electronic components and more.
A much less invasive way to monitor pressure in the brain
New technique could help doctors determine whether patients are at risk from elevated pressure.
Study links certain metabolites to stem cell function in the intestine
Molecules called ketone bodies may improve stem cells’ ability to regenerate new intestinal tissue.
Tissue model reveals role of blood-brain barrier in Alzheimer’s
Study finds that Alzheimer’s damage allows toxins to enter the brain, further harming neurons.
Speeding up drug discovery for brain diseases
Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.