Genetic screen offers new drug targets for Huntington’s disease
Neuroscientists identify genes that modulate the disease’s toxic effects.
Putting a finger on the switch of a chronic parasite infection
Researchers find master regulator needed for Toxoplasma gondii parasite to chronically infect host; promising step toward infection treatment, prevention.
American Physical Society honors three MIT professors for physics research
James Collins, Pablo Jarillo-Herrero, and Richard Milner have won top prizes for their work.
Using CRISPR to program gels with new functions
Smart materials change properties in response to specific DNA sequences; could be used in a variety of devices.
High-precision technique stores cellular “memory” in DNA
Engineers program human and bacterial cells to keep a record of complex molecular events.
Speeding up drug discovery for brain diseases
Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.
New CRISPR platform expands RNA editing capabilities
The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.
Using gene editing, neuroscientists develop a new model for autism
By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.
New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
Keeping genetic engineering localized
Researchers are developing a so-called "daisy-chain" gene-drive system that provides controls for genetic engineering of certain populations.
Academic institutions grant commercial license for CRISPR-based SHERLOCK diagnostic technology in developed world
Rights are protected for broad use in developing world and for public health needs.
Scientists engineer new CRISPR platform for DNA targeting
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
New CRISPR tool opens up more of the genome for editing
Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.
Feng Zhang wins 2018 Keio Medical Science Prize
McGovern Institute scientist is recognized with award for outstanding and creative achievements made in the life and medical sciences.
Scientists sharpen the edges of cancer chemotherapy
Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.