Basic cell health systems wear down in Huntington’s disease, analysis shows
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.
Metabolic mutations help bacteria resist drug treatment
Study suggests forcing bacteria to burn more energy could make them more susceptible to antibiotics.
3 Questions: Lindsay Case on how cells organize and sense the world
Case’s new lab investigates why cancer arises when disruptions in cellular organization change how cells sense mechanical forces.
Catching cancer in the act
Using CRISPR technology, researchers are tracking the lineage of individual cancer cells as they proliferate and metastasize in real-time.
Why cancer cells waste so much energy
MIT study sheds light on the longstanding question of why cancer cells get their energy from fermentation.
“SCOUT” helps researchers find, quantify significant differences among organoids
Unbiased, high-throughput analysis pipeline improves utility of “minibrains” for understanding development and diseases such as Zika infection.
MIT launches Center for Multi-Cellular Engineered Living Systems
M-CELS are purpose-driven living systems with multiple interacting living components.
SMART researchers develop gelatin microcarrier for cell production
Gelatin-based microcarriers offer higher yield and scalability compared to existing commercial microcarriers.
Truncated immune system receptors may regulate cellular activity
Unexpected findings in chemokine receptors once believed to be non-functional open up new fields of scientific inquiry.
To make mini-organs grow faster, give them a squeeze
Study finds that compressing cells, and crowding their contents, can coax them to grow and divide.
Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help
Astrocytes with the APOE4 gene variant show deficits of a key cellular function, but overexpressing the gene PICALM overcame the defect.
SMART researchers receive Intra-CREATE grant for personalized medicine and cell therapy
Funds will support research on glaucoma through retinal biometrics and neural cell implantation therapy for spinal cord injury.
Proteins — and labs — coming together to prevent Rett syndrome
Disruption of condensates in the neurodevelopmental disorder provides insights into how cells compartmentalize chromosomes, as well as new potential therapies.
Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA
Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.
Pyae Phyo: From Myanmar to NMR
PhD candidate’s journey to the center of the plant cell wall relies on nuclear magnetic resonance technology.