McGovern Institute

MIT researchers have developed a light-sensitive protein that can be embedded into neuron membranes, where it emits a fluorescent signal that indicates how much voltage a particular cell is experiencing. This could allow scientists to study how neurons behave, millisecond by millisecond, as the brain performs a particular function.

Seeing the brain's electrical activity

Fluorescent sensor allows imaging of neurons' electrical communications, without electrodes.

February 26, 2018

A collection of SHERLOCK paper test strips. (Left) Unused paper strips, (middle) paper tests displaying a negative SHERLOCK readout, and (right) paper tests displaying a positive SHERLOCK readout.

Researchers advance CRISPR-based tool for diagnosing disease

With SHERLOCK, a strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest.

February 15, 2018

MIT cognitive scientists have found that conversation between an adult and a child appears to change the child’s brain.

Back-and-forth exchanges boost children’s brain response to language

Study finds engaging young children in conversation is more important for brain development than “dumping words” on them.

February 13, 2018

This image shows neurons in the CA3 region of the hippocampus, which is important for memory encoding and retrieval. Nuclei of the CA3 neurons are labeled in green and their dendrites in red, and the smaller specks of green above represent axons projecting to the CA3 neurons from the dentate gyrus.

Study reveals molecular mechanisms of memory formation

Neuroscientists discover a cellular pathway that encodes memories by strengthening specific synapses.

February 8, 2018

Our daily lives include hundreds of routine habits, made up of many smaller actions, such as picking up our toothbrush, squeezing toothpaste onto it, and then lifting the brush to our mouth. This process of grouping behaviors together into a single routine is known as “chunking.” MIT neuroscientists have now found that certain neurons in the brain are responsible for marking the beginning and ...

Distinctive brain pattern helps habits form

Study identifies neurons that fire at the beginning and end of a behavior as it becomes a habit.

February 8, 2018

From left to right: Polina Anikeeva, the Class of 1942 Associate Professor in the Department of Materials Science and Engineering and associate director of the Research Laboratory of Electronics, and Feng Zhang, the James and Patricia Poitras ’63 Professor in Neuroscience at the McGovern Institute, a core member of the Broad Institute, and an associate professor in the departments of Brain and C...

Polina Anikeeva and Feng Zhang awarded 2018 Vilcek Prize

Prize recognizes contributions to biomedical research made by immigrant scientists.

February 1, 2018

Dagdeviren (center) developed the device while working as a postdoc in the labs of Graybiel (left), Cima (right), and Langer (far left).

Ultrathin needle can deliver drugs directly to the brain

Miniaturized system could be used to treat neurological disorders that affect specific brain regions.

January 24, 2018

School of Science Infinite Kilometer Awards for 2017

Eight research staffers and postdocs are recognized for their extraordinary contributions and dedication to programs, colleagues, and the Institute.

January 16, 2018

This spring's additions to the School of Science faculty: (left to right) Michael Halassa, Brent Minchew, and Alexander "Sasha" Rakhlin

School of Science welcomes three new professors this spring

January 11, 2018

A new study from MIT researchers provides evidence for an alternative timekeeping system that relies on the neurons responsible for producing a specific action. Depending on the time interval required, these neurons compress or stretch out the steps they take to generate the behavior at a specific time.

How the brain keeps time

Neuroscientists discover networks of neurons that stretch or compress their activity to control timing.

December 4, 2017

To evaluate infants’ intuition regarding what other people value, researchers showed them videos in which an agent (red bouncing ball) decides whether it’s worth the effort to leap over an obstacle to reach a goal (blue cartoon character).

How badly do you want something? Babies can tell

Ten-month-old infants determine the value of a goal from how hard someone works to achieve it.

November 23, 2017

MIT neuroscientists have discovered that making decisions, especially when choosing between two options that have both positive and negative elements, can be dramatically affected by chronic stress.

Stress can lead to risky decisions

Neuroscientists find chronic stress skews decisions toward higher-risk options.

November 16, 2017

MIT researchers have devised a way to control single neurons using optogenetics. To help achieve this, they developed an opsin, or light-sensitive protein, that can be targeted to neuron cell bodies (bottom row). Neurons in the top row have traditional opsins that are distributed throughout their axons.

Next-generation optogenetic molecules control single neurons

Focused laser beam could help scientists map connections among neurons that underlie behavior.

November 13, 2017

A new “REPAIR” system edits RNA, rather than DNA.

Researchers engineer CRISPR to edit single RNA letters in human cells

“REPAIR” system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome.

October 25, 2017

Ten from MIT and the Broad Institute recently received NIH Director's Awards. Top row (l-r): Feng Zhang, Kay Tye, Kevin Esvelt, Fei Chen; Bottom row (l-r): Gabriela Schlau-Cohen, Ahmed Badran, Hilary Finucane, Ed Boyden. Not pictured: Paul Blainey and Evan Macosko.

Ten researchers from MIT and Broad receive NIH Director’s Awards

Awards support high-risk, high-impact biomedical research.

October 5, 2017

MIT News | Massachusetts Institute of Technology

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