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In certain species of bacteria, the answer lies in shielding RNA transcripts from a quality-control factor called Rho. Understanding the requirements for expressible sequences is critical for expression engineering of therapeutic agents.
Neural interaction with bacteria has important effects on animal brains. A new study investigates how neurons sense bacteria by revealing, in nematodes, the bacterial signals that a key neuron detects.
MIT scientists create a detailed map of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones.
SNIPE, a newly characterized biological defense system, directly protects bacteria by chopping up invading viral DNA.
Researchers uncovered how cells selectively destroy certain microRNAs — key gene regulators — through a mechanism that requires two RNA signals working together.
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
Time and again, an unassuming roundworm has illuminated aspects of biology with major consequences for human health.
Researchers developed an approach to study where proteins get made, and characterized proteins produced near mitochondria, gaining potential insights into mitochondrial function and disease.
Researchers develop a fast-acting, cell-permeable protein system to control CRISPR-Cas9, reducing off-target effects and advancing gene therapy.
Researchers developed a tool to recreate cells’ family trees. Comparing cells’ lineages and locations within a tumor provided insights into factors shaping tumor growth.
The approach collects multiple types of imaging and sequencing data from the same cells, leading to new insights into mouse liver biology.
Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.
Study shows how a dopamine circuit enables mice to extinguish fear after a peril has passed, opening new avenues for understanding and potentially treating fear-related disorders.
Upon infection, the C. elegans worm reshuffles the roles of brain cells and flips the functions of some of the chemicals it uses to regulate behavior.
Since an MIT team introduced expansion microscopy in 2015, the technique has powered the science behind kidney disease, plant seeds, the microbiome, Alzheimer’s, viruses, and more.