A better DNA material for genetic medicine
With its circular single-stranded DNA molecules, MIT spinout Kano Therapeutics plans to make gene and cell therapies safer and more effective.
Alternate proteins from the same gene contribute differently to health and rare disease
New findings may help researchers identify genetic mutations that contribute to rare diseases, by studying when and how single genes produce multiple versions of proteins.
A new way to understand and predict gene splicing
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.
Solar energy startup Active Surfaces wins inaugural PITCH.nano competition
Twelve START.nano companies competed for the grand prize of nanoBucks to be used at MIT.nano’s facilities.
In a surprising discovery, scientists find tiny loops in the genomes of dividing cells
Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide.
A new system can dial expression of synthetic genes up or down
The promoter editing system could be used to fine-tune gene therapy or to more efficiently reprogram cells for therapeutic use.
A more precise way to edit the genome
MIT researchers have dramatically lowered the error rate of prime editing, a technique that holds potential for treating many genetic disorders.
This MIT spinout is taking biomolecule storage out of the freezer
Cache DNA has developed technologies that can preserve biomolecules at room temperature to make storing and transporting samples less expensive and more reliable.
Study explains how a rare gene variant contributes to Alzheimer’s disease
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.
Study finds cell memory can be more like a dimmer dial than an on/off switch
The findings may redefine how cell identity is established and enable the creation of more sophisticated engineered tissues.
Remembering David Baltimore, influential biologist and founding director of the Whitehead Institute
The longtime MIT professor and Nobel laureate was a globally respected researcher, academic leader, and science policy visionary who guided the careers of generations of scientists.
Mapping cells in time and space: New tool reveals a detailed history of tumor growth
Researchers developed a tool to recreate cells’ family trees. Comparing cells’ lineages and locations within a tumor provided insights into factors shaping tumor growth.
Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets
Combining powerful imaging, perturbational screening, and machine learning, researchers uncover new human host factors that alter Ebola’s ability to infect.
How to more efficiently study complex treatment interactions
A new approach for testing multiple treatment combinations at once could help scientists develop drugs for cancer or genetic disorders.
New method combines imaging and sequencing to study gene function in intact tissue
The approach collects multiple types of imaging and sequencing data from the same cells, leading to new insights into mouse liver biology.