Angela Koehler takes on the most challenging drug targets
Using biological, chemical, and engineering tools, she has developed strategies to attack molecules once thought to be “undruggable.”
The economics of missed opportunities
Danielle Li takes a close look at scientific practices and organizational decisions — and provides data about improving them.
Artificial intelligence model can detect Parkinson’s from breathing patterns
An MIT-developed device with the appearance of a Wi-Fi router uses a neural network to discern the presence and severity of one of the fastest-growing neurological diseases in the world.
Artificial intelligence model finds potential drug molecules a thousand times faster
A geometric deep-learning model is faster and more accurate than state-of-the-art computational models, reducing the chances and costs of drug trial failures.
Can artificial intelligence overcome the challenges of the health care system?
MIT and Mass General Brigham researchers and physicians connect in person to bring AI into mainstream health care.
3 Questions: Daniel Anderson on the progress of mRNA vaccines
Following the successful development of vaccines against Covid-19, scientists hope to deploy mRNA-based therapies to combat many other diseases.
Q&A: Chris Rackauckas on the equations at the heart of practically everything
Have a question about numerical differential equations? Odds are this CSAIL research affiliate has already addressed it.
A smarter way to develop new drugs
A new artificial intelligence technique only proposes candidate molecules that can actually be produced in a lab.
An “oracle” for predicting the evolution of gene regulation
Researchers create a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA.
SMART researchers discover unique lysin capable of killing multidrug-resistant bacteria
Novel lysin Abp013 has shown promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae.
Chemical synthesis yields potential antibiotic
A new strategy for producing a natural compound could also be used to generate variants with even stronger antimicrobial activity.
Measuring cancer cell state can reveal drug susceptibility
Study results also show that pancreatic tumor cells can be forced into a more susceptible state by changing their environment.
Taking some of the guesswork out of drug discovery
A deep learning model rapidly predicts the 3D shapes of drug-like molecules, which could accelerate the process of discovering new medicines.
Engineers devise a way to selectively turn on RNA therapies in human cells
A new RNA-based control switch could be used to trigger production of therapeutic proteins to treat cancer or other diseases.
Chronicles of the epic mission to deliver Covid vaccines to the world
“A Shot in the Arm,” a new book from Professor Yossi Sheffi, reveals lessons about overcoming global threats.