New CRISPR-based tool inserts large DNA sequences at desired sites in cells
Known as PASTE, the technique holds potential for treating a variety of diseases caused by faulty genes.
Scientists unveil the functional landscape of essential genes
Researchers harness new pooled, image-based screening method to probe the functions of over 5,000 essential genes in human cells.
A new control system for synthetic genes
Researchers have developed a technique that could help fine-tune the production of monoclonal antibodies and other useful proteins.
A “door” into the mitochondrial membrane
Study finds the protein MTCH2 is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and MTCH2-linked conditions.
MIT scientists discover new antiviral defense system in bacteria
Prokaryotes can detect hallmark viral proteins and trigger cell death through a process seen across all domains of life.
New CRISPR-based map ties every human gene to its function
Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.
Convenience-sized RNA editing
MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.
New research center focused on brain-body relationship established at MIT
K. Lisa Yang Brain-Body Center to investigate the brain’s complex relationship with other body systems.
Tracing a cancer’s family tree to its roots reveals how tumors grow
Family trees of lung cancer cells reveal how cancer evolves from its earliest stages to an aggressive form capable of spreading throughout the body.
Advocating for vaccine equity
Postdoc Digbijay Mahat became a cancer researcher to improve health care in Nepal, but the Covid-19 pandemic exposed additional resource disparities.
Mentorship and medicine
MIT senior Daniel Zhang aims to provide hope for young patients and support to young students.
Illuminating the history and global story of antibiotics
HASTS PhD student Rijul Kochhar tracks changing medical and microbial realities, and examines what they portend for society.
Six with MIT ties elected to the National Academy of Medicine for 2021
Professors Linda Griffith and Feng Zhang along with Guillermo Ameer ScD ’99, Darrell Gaskin SM ’87, William Hahn, and Vamsi Mootha recognized for contributions to medicine, health care, and public health.
RNA-targeting enzyme expands the CRISPR toolkit
Exploring diversity among bacterial immune systems, McGovern Institute scientists uncovere a programmable system for precisely targeting and modifying RNA.
New programmable gene editing proteins found outside of CRISPR systems
Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.