Unlocking mRNA’s cancer-fighting potential
MIT spinout Strand Therapeutics has developed a new class of mRNA molecules that can sense where they are in the body, for more targeted and powerful treatments.
Study: Movement disorder ALS and cognitive disorder FTLD show strong molecular overlaps
Single-cell gene expression patterns in the brain, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.
Exploring the cellular neighborhood
Software allows scientists to model shapeshifting proteins in native cellular environments.
How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice
Study finds stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of an Alzheimer’s protein.
Deciphering the cellular mechanisms behind ALS
Professor Ernest Fraenkel has decoded fundamental aspects of Huntington’s disease and glioblastoma, and is now using computation to better understand amyotrophic lateral sclerosis.
Scientists develop a low-cost device to make cell therapy safer
A plastic microfluidic chip can remove some risky cells that could potentially become tumors before they are implanted in a patient.
Blood cell family trees trace how production changes with aging
Jonathan Weissman and collaborators developed a tool to reconstruct human cell family trees, revealing how blood cell production changes in old age.
Capsid of HIV-1 behaves like cell’s cargo receptor to enter the nucleus
Biologists demonstrate that HIV-1 capsid acts like a Trojan horse to pass viral cargo across the nuclear pore.
How cell identity is preserved when cells divide
MIT study suggests 3D folding of the genome is key to cells’ ability to store and pass on “memories” of which genes they should express.
Wobbly gel mat trains muscle cells to work together
The vibrating platform could be useful for growing artificial muscles to power soft robots and testing therapies for neuromuscular diseases.
A more effective experimental design for engineering a cell into a new state
By focusing on causal relationships in genome regulation, a new AI method could help scientists identify new immunotherapy techniques or regenerative therapies.
3 Questions: Daniel Lew on what we can learn about cells from yeast
New professor of biology uses budding yeast to address fundamental questions in cell biology.
Study connects neural gene expression differences to functional distinctions
Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function.
AI models are powerful, but are they biologically plausible?
A new study bridging neuroscience and machine learning offers insights into the potential role of astrocytes in the human brain.
Study explains how part of the nucleolus evolved
A single protein can self-assemble to build the scaffold for a biomolecular condensate that makes up a key nucleolar compartment.