Cancer

Early research from MIT scientists suggests that over time a high-fat diet can impact the liver in a way that may raise the risk of cancer. “When the liver repeatedly processes large amounts of fat, its main working cells stop focusing on breaking down nutrients and filtering toxins,” writes Deirdre Bardolf for Fox News. “They revert to a more primitive state to help them endure the strain of a fatty diet, a shift researchers associate with tumorigenesis, the process by which cancer can develop.” 

Prof. Canan Dagdeviren speaks with Bloomberg Businessweek Daily reporters Carol Massar and Tim Stenovec about her work developing conformable ultrasound technology aimed at enabling earlier breast cancer detection. “This technology can be a part of your personal bra, and you can wear it and while drinking your coffee within seconds, it can tell you [about] any anomaly with pinpoint accuracy,” Dagdeviren explains. 

WBUR reporter Rachell Sanchez-Smith spotlights two health tech devices being developed by Prof. Yoel Fink and Prof. Canan Dağdeviren, respectively, that aim to “give the wearers — and their doctors — a clearer picture of their overall health.” Fink has created “a thread capable of storing data, running artificial intelligence algorithms, sensing motion and sound, and communication through Bluetooth,” while Dağdeviren’s wearable ultrasound scanner can be used to make breast cancer screening “more comfortable and more accurate,” explains Sanchez-Smith.  

Strand Therapeutics, co-founded Jake Becraft PhD '19, has developed a programmable drug that could one day shrink tumors in cancer patients, reports Amy Feldman for Forbes. “It shocked even us,” says Becraft. “You hope something happens, but you don’t expect to see a huge response because these patients have already proven to have cancers so resistant to treatment.” 

Writing for GBH, graduate students and alumni Jessica Chomik-Morales, Sarah Akaaboune, Mackenzie White '25, Celina Zhao '24, SM '25, spotlight the Dana-Farber mobile Mammogram Van. “The unit meets women where they live and work, offering care in the languages they speak,” they write. “By bringing screenings to neighborhoods with large Asian and other minority populations, the van shows how community-based, culturally responsive care can reduce disparities and improve access to critical health resources.” 

Prof. Canan Dagdeviren speaks with NBC Boston  reporter Priscilla Casper about her work developing a wearable ultrasound scanner that can be used for early breast cancer detection, with the goal of empowering “women to monitor their own bodies, on their own time and in the comfort of their own home.” Dagdeviren explains that “our hope [is to] collect a lot of data and use AI to predict what will happen to breast tissue over time.”   

Chronicle visits MIT to learn more about how the Institute “nurtures groundbreaking efforts, reminding us that creativity and science thrive together, inspiring future advancements in engineering, medicine, and beyond.” Prof. Julien de Wit and Research Scientist Artem Burdanov discuss their planetary defense efforts aimed at identifying small asteroids that could pose a threat to Earth, and Prof. Canan Dağdeviren demonstrates her work developing ultrasound devices to detect the earliest stages of breast cancer. Host Anthony Everett notes that: “Big ideas have a way of breaking out of conventional boundaries, just part of what makes MIT one giant laboratory of groundbreaking ideas."

Scientific American reporter Nic Flemming spotlights research by Prof. Ömer Yilmaz and his team, which explores the impact of fasting on intestinal stem cells. “Both caloric restriction and fasting improved intestinal stem-cell activity and health, but the mechanisms involved are very different,” says Yilmaz. 

MIT researchers have developed a technique to use a damage suppressing protein called “Dsup” to help protect cancer patients from the side effects of radiation therapy, writes Shane Galvin for The New York Post. “Scientists, encouraged by this remarkable discovery, believe they can create an upgraded version of Dsup which can be used to radiation-proof human cells without any unwanted drawbacks,” writes Galvin. “They also believe that the protein could be used by astronauts to prevent space-related radiation [damage].” 

Researchers at MIT and elsewhere have found that a protein developed by tardigrades could be used to help protect cancer patients from the side effects of radiation therapy, reports Ed Cara for Gizmodo. “The findings could someday lead to an invaluable add-on treatment for many cancer patients,” writes Cara. He adds that the new technique “could even possibly be used to protect astronauts from space-related radiation or to protect cancer patients from other sources of treatment-induced DNA damage, such as chemotherapy drugs.”

According to a new study co-authored by researchers at MIT, harnessing the damage suppressor protein found in tardigrades, a microscopic organism known for its resilience, could help ease the impacts of radiation therapy on cancer patients. “The Dsup protein, which binds directly to DNA and reduces radiation-induced strand breaks, immediately struck us as a promising tool to mitigate normal tissue injury during radiotherapy,” Prof. Giovanni Traverso explains to Corinna Singleman of Genetic Engineering & Biotechnology News. 

Writing for Forbes, Paula Schneider, CEO of Susan G. Komen, highlights Prof. Regina Barzilay’s research using AI to detect breast cancer. “Using her own mammograms in her research at MIT, Dr. Barzilay demonstrated how AI could have detected her breast cancer much earlier, potentially improving her prognosis,” writes Schneider. “Studies show that incorporating AI into mammogram analysis boosts cancer detection rates by 20%, without increasing false positives. This is a significant leap forward, as early detection is key to a better chance at positive outcomes and survival.” 

MIT Profs. Angela Belcher, Emery Brown, Paula Hammond and Feng Zhang have been honored with National Medals of Science and Technology, reports Michael T. Neitzel for Forbes. Additionally, R. Lawrence Edwards '76 received a National Medal of Science and Noubar Afeyan PhD '87, a member of the MIT Corporation, accepted a National Medal on behalf of Moderna. The recipients have been awarded “the nation’s highest honors for exemplary achievements and leadership in science and technology,” explains Neitzel. 

Researchers at MIT have developed a new AI model capable of assessing a patient’s risk of pancreatic cancer, reports Erez Meltzer for Forbes. “The model could potentially expand the group of patients who can benefit from early pancreatic cancer screening from 10% to 35%,” explains Meltzer. “These kinds of predictive capabilities open new avenues for preventive care.” 

Profs. Canan Dagdeviren and Hugh Herr speak with CNN discuss their work aimed at empowering patients and doctors. Inspired by her aunt’s experience with breast cancer, Dagdeviren and her students are developing new wearable devices that could help detect cancer at an earlier stage. Says Herr of his work developing prosthetics that can be controlled by the human nervous system: “There will be a point where technology is so sophisticated that we can actually rebuild limbs after amputation that will be as good and, ultimately, they will be better than intact biological limbs.” Herr adds that in the future he hopes “the conversation will not be about human limitation anymore. It will be about human ability and human expression.”