AI maps how a new antibiotic targets gut bacteria
MIT CSAIL and McMaster researchers used a generative AI model to reveal how a narrow-spectrum antibiotic attacks disease-causing bacteria, speeding up a process that normally takes years.
Using generative AI, researchers design compounds that can kill drug-resistant bacteria
The team used two different AI approaches to design novel antibiotics, including one that showed promise against MRSA.
Protein study could help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
Scientists identify mechanism behind drug resistance in malaria parasite
SMART researchers find a cellular process called transfer ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance.
When an antibiotic fails: MIT scientists are using AI to target “sleeper” bacteria
Most antibiotics target metabolically active bacteria, but with artificial intelligence, researchers can efficiently screen compounds that are lethal to dormant microbes.
Using AI, MIT researchers identify a new class of antibiotic candidates
These compounds can kill methicillin-resistant Staphylococcus aureus (MRSA), a bacterium that causes deadly infections.
Newly discovered bacterial communication system aids antimicrobial resistance
SMART researchers find the enzyme RlmN, which directly senses chemical and environmental stresses, can be targeted in drug development.
A novel combination therapy counters antibiotic-resistant Mycobacterium abscessus infections
SMART researchers combine rifaximin and clarithromycin to effectively restore the latter drug's efficacy.
Using AI, scientists find a drug that could combat drug-resistant infections
The machine-learning algorithm identified a compound that kills Acinetobacter baumannii, a bacterium that lurks in many hospital settings.
A novel combination therapy for treating vancomycin-resistant bacterial infections
Developed at SMART, the therapy stimulates the host immune system to more effectively clear bacterial infections and accelerate infected wound healing.
Christopher Walsh, influential chemical biologist and former department chair at MIT, dies at 79
Beloved professor and “titan of chemical biology” spent 15 years on the MIT faculty, leading the Department of Chemistry from 1982 to 1987.
Analyzing the potential of AlphaFold in drug discovery
Study finds computer models that predict molecular interactions need improvement before they can help identify drug mechanisms of action.
Nanoparticle sensor can distinguish between viral and bacterial pneumonia
Using this diagnostic, doctors could avoid prescribing antibiotics in cases where they won’t be effective.
New gels could help the medicine go down
Mixing drugs into oil-based gels could offer relief for children and adults who have trouble swallowing pills.
Engineered bacteria could help protect “good” gut microbes from antibiotics
Microbes that safely break down antibiotics could prevent opportunistic infections and reduce antibiotic resistance.