McRose, an environmental microbiologist, is recognized for researching the ecological roles of antibiotics in shaping ecosystems, agriculture, and health.
MIT CSAIL and McMaster researchers used a generative AI model to reveal how a narrow-spectrum antibiotic attacks disease-causing bacteria, speeding up a process that normally takes years.
The team used two different AI approaches to design novel antibiotics, including one that showed promise against MRSA.
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
SMART researchers find a cellular process called transfer ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance.
Most antibiotics target metabolically active bacteria, but with artificial intelligence, researchers can efficiently screen compounds that are lethal to dormant microbes.
These compounds can kill methicillin-resistant Staphylococcus aureus (MRSA), a bacterium that causes deadly infections.
SMART researchers find the enzyme RlmN, which directly senses chemical and environmental stresses, can be targeted in drug development.
SMART researchers combine rifaximin and clarithromycin to effectively restore the latter drug's efficacy.
The machine-learning algorithm identified a compound that kills Acinetobacter baumannii, a bacterium that lurks in many hospital settings.
Developed at SMART, the therapy stimulates the host immune system to more effectively clear bacterial infections and accelerate infected wound healing.
Beloved professor and “titan of chemical biology” spent 15 years on the MIT faculty, leading the Department of Chemistry from 1982 to 1987.
Study finds computer models that predict molecular interactions need improvement before they can help identify drug mechanisms of action.
Using this diagnostic, doctors could avoid prescribing antibiotics in cases where they won’t be effective.
Mixing drugs into oil-based gels could offer relief for children and adults who have trouble swallowing pills.