How Tau tangles form in the brain
A new study shows that truncated versions of the Tau protein are more likely to form the sticky filaments seen in the brains of people with Alzheimer’s disease.
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.
From labs to the streets, experts work to defuse childhood threats to mental health
Symposium speakers describe numerous ways to promote prevention, resilience, healing, and wellness after early-life stresses.
40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models
Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows.
Neuroscientists identify cells especially vulnerable to Alzheimer’s
Neurons that form part of a memory circuit are among the first brain cells to show signs of neurodegeneration in Alzheimer’s disease.
A new peptide may hold potential as an Alzheimer’s treatment
The peptide blocks a hyperactive brain enzyme that contributes to the neurodegeneration seen in Alzheimer’s and other diseases.
Researchers map brain cell changes in Alzheimer’s disease
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.
Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
Longtime MIT professor of neuroscience led research behind 200 patents, laying the groundwork for numerous medical products.
Small studies of 40-hertz sensory stimulation confirm safety, suggest Alzheimer’s benefits
MIT researchers report early-stage clinical study results of tests with noninvasive 40-hertz light and sound treatment.
Alzheimer’s risk gene undermines insulation of brain’s “wiring”
In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.
A “door” into the mitochondrial membrane
Study finds the protein MTCH2 is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and MTCH2-linked conditions.
Celebrating 20 years of discovery, Picower Institute looks ahead to continuing impact
At an exhibition marking two decades since a transformative gift from the Picower Foundation, current and alumni members described research at the forefront of neuroscience and beyond.
With fractured genomes, Alzheimer’s neurons call for help
Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.
Neurodegenerative disease can progress in newly identified patterns
A machine-learning method finds patterns of health decline in ALS, informing future clinical trial designs and mechanism discovery. The technique also extends to Alzheimer’s and Parkinson’s.