With fractured genomes, Alzheimer’s neurons call for help
Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.
Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.
A machine-learning method finds patterns of health decline in ALS, informing future clinical trial designs and mechanism discovery. The technique also extends to Alzheimer’s and Parkinson’s.
“We can’t think of the brain only as neurons,” says PhD student Mitch Murdock, who explores the cellular basis of Alzheimer’s disease.
Research reveals cells that span brain hemispheres to coordinate activity in visual processing centers, shows Alzheimer’s degrades their structure and function.
A breakdown of lipid metabolism in these brain cells promotes inflammation and interferes with neuron activity, a new study finds.
Two types of tau proteins mix together in a nearly random way to generate the tangles seen in the brains of Alzheimer’s patients.
Competitive seed grants launch yearlong investigations of novel hypotheses about potential causes, biomarkers, treatments of Alzheimer’s and ALS.
The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia.
The visual cortex stores and remembers individual images, but mice can’t recognize image sequences without guidance from the hippocampus.
To quickly express learning and memory genes, brain cells snap both strands of DNA in many more places and cell types than previously realized, a new study shows.
How 3D-printed models of neuronal axons could accelerate development of new therapies to treat neurodegenerative disorders.
Selective global honor supports early-career scientists and engineers in taking on new pursuits.
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline supplements.
Speakers describe studies to address Alzheimer’s disease, sleep apnea, and to advance fundamental discoveries in cell and chromosome biology.