Koch Institute

Research reveals that the external environment of epithelial cells influences the fidelity of chromosome segregation. Hepatocytes proliferating in regenerating livers, such as the mitotic cell shown here with a mitotic spindle (green) capturing chromosomes (blue), are able to accurately segregate chromosomes, whereas hepatocytes dividing in culture have high levels of chromosome missegregation.

Tissue architecture affects chromosome segregation

Biologists discover that the environment surrounding a cell plays an integral role in its ability to accurately segregate its chromosomes.

August 23, 2018

Chronic rhinosinusitis causes the sinuses to become inflamed and swollen for months to years at a time, leading to difficulty breathing and other symptoms.

Study: Cellular changes lead to chronic allergic inflammation in the sinus

Findings suggest mechanisms for the persistence of nasal polyps and possible new treatment strategies.

August 22, 2018

The inaugural class of Convergence Scholars: (l-r) Ritu Raman, Liang Hao, Natalie Boehnke, Briana Dunn, Jacob Martin, and Kaitlyn Sadtler

Preparing postdocs for life beyond the bench

The new Convergence Scholars Program bridges disciplines and helps young researchers further their skills and build their brands as scientists.

August 16, 2018

A new study from MIT and Massachusetts Eye and Ear has found that glaucoma may in fact be an autoimmune disorder.

Study suggests glaucoma may be an autoimmune disease

Unexpected findings show that the body’s own immune system destroys retinal cells.

August 10, 2018

A team of researchers hopes to extend patients’ lifespan by delivering directly to the brain a drug that targets a mutation found in 20 to 25 percent of all gliomas.

A targeted approach to treating glioma

With new method, surgeons would remove tumor, then implant microparticles that attack remaining cancer cells.

August 6, 2018

School of Engineering second quarter 2018 awards

Faculty members recognized for excellence via a diverse array of honors, grants, and prizes over the last quarter.

July 17, 2018

MIT researchers have designed nanoparticles that can deliver messenger RNA to specific organs. In this image, lung cells expressing the synthetic mRNA show up as red.

New materials improve delivery of therapeutic messenger RNA

Polymeric nanoparticles can efficiently administer mRNA to cells of the lungs, liver, and other organs.

July 16, 2018

MIT engineers have designed nanoparticles that can be attached to T cells and release T-cell-stimulating molecules called cytokines (yellow spheres). These cytokines activate T cells (blue) to attack nearby tumor cells.

Nanoparticles give immune cells a boost

Drugs carried in cellular “backpacks” help T cells to destroy tumors.

July 9, 2018

This osteosarcoma cell appears with DNA in blue, mitochondria in yellow, and actin filaments in purple.

Restricting a key cellular nutrient could slow tumor growth

Researchers identify the amino acid aspartate as a metabolic limitation in certain cancers.

June 28, 2018

This image shows pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red).

Biologists discover how pancreatic tumors lead to weight loss

Shortfall of digestive enzymes can lead to tissue breakdown in early stages of pancreatic cancer.

June 20, 2018

Researchers derived a single Paneth cell with anti-microbial granules in red and green from an adult intestinal stem cell.

Charting a path to better cell models of the intestine

Researchers generate an intestinal cell mimic that can be harnessed in studies of diseases such as inflammatory bowel disease.

June 19, 2018

Robert Langer named 2018 US Science Envoy

Institute Professor chosen to help forge connections and identify opportunities for sustained international cooperation.

June 18, 2018

Researchers have taken an in-depth look at RNA-protein interactions, determining the sequence, structure, and context preferences of RNA-binding proteins in a high throughput manner.

Decoding RNA-protein interactions

Scientists leverage one step, unbiased method to characterize the binding preferences of more than 70 human RNA-binding proteins.

June 7, 2018

MIT researchers, working with scientists from Brigham and Women’s Hospital, have developed a new way to power and communicate with devices implanted deep within the human body.

Wireless system can power devices inside the body

New technology could enable remote control of drug delivery, sensing, and other medical applications.

June 4, 2018

MIT researchers have designed brain-tumor-targeting nanoparticles that can carry two different drugs, one in the core and one in the outer shell.

Tiny particles could help fight brain cancer

Nanoparticles carrying two drugs can cross the blood-brain barrier and shrink glioblastoma tumors.

May 24, 2018

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