A boost for the precision of genome editing
Researchers develop a fast-acting, cell-permeable protein system to control CRISPR-Cas9, reducing off-target effects and advancing gene therapy.
Researchers glimpse the inner workings of protein language models
A new approach can reveal the features AI models use to predict proteins that might make good drug or vaccine targets.
Using generative AI, researchers design compounds that can kill drug-resistant bacteria
The team used two different AI approaches to design novel antibiotics, including one that showed promise against MRSA.
How the brain distinguishes oozing fluids from solid objects
A new study finds parts of the brain’s visual cortex are specialized to analyze either solid objects or flowing materials like water or sand.
Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets
Combining powerful imaging, perturbational screening, and machine learning, researchers uncover new human host factors that alter Ebola’s ability to infect.
How to more efficiently study complex treatment interactions
A new approach for testing multiple treatment combinations at once could help scientists develop drugs for cancer or genetic disorders.
Implantable device could save diabetes patients from dangerously low blood sugar
The new implant carries a reservoir of glucagon that can be stored under the skin and deployed during an emergency — with no injections needed.
MIT chemists boost the efficiency of a key enzyme in photosynthesis
The enzyme, known as rubisco, helps plants and photosynthetic bacteria incorporate carbon dioxide into sugars.
MIT and Mass General Hospital researchers find disparities in organ acceptance
In an analysis of over 160,000 transplant candidates, researchers found that race is linked to how likely an organ offer is to be accepted on behalf of a patient.
Study: Babies’ poor vision may help organize visual brain pathways
MIT researchers found that low-quality visual input early in life may contribute to the development of key pathways in the brain’s visual system.
MIT Open Learning bootcamp supports effort to bring invention for long-term fentanyl recovery to market
The Substance Use Disorders Ventures Bootcamp ignites innovators like Evan Kharasch to turn research breakthroughs into treatments for substance use disorder.
Supercharged vaccine could offer strong protection with just one dose
By delivering an HIV vaccine candidate along with two adjuvants, researchers showed they could generate many more HIV-targeting B cells in mice.
MIT students and postdoc explore the inner workings of Capitol Hill
In an annual tradition, MIT affiliates embarked on a trip to Washington to explore federal lawmaking and advocate for science policy.
A high-fat diet sets off metabolic dysfunction in cells, leading to weight gain
Researchers also found these effects can be reversed by treatment with an antioxidant.
Scientists discover potential new targets for Alzheimer’s drugs
Pathways involved in DNA repair and other cellular functions could contribute to the development of Alzheimer’s.