Brain circuit needed to incorporate new information may be linked to schizophrenia
Impairments of this circuit may help to explain why some people with schizophrenia lose touch with reality.
3 Questions: Building predictive models to characterize tumor progression
Assistant Professor Matthew Jones is working to decode molecular processes on the genetic, epigenetic, and microenvironment levels to anticipate how and when tumors evolve to resist treatment.
AI to help researchers see the bigger picture in cell biology
By providing holistic information on a cell, an AI-driven method could help scientists better understand disease mechanisms and plan experiments.
New AI model could cut the costs of developing protein drugs
MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, making production more efficient.
Designing the future of metabolic health through tissue-selective drug delivery
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
3 Questions: Using computation to study the world’s best single-celled chemists
Assistant Professor Yunha Hwang utilizes microbial genomes to examine the language of biology. Her appointment reflects MIT’s commitment to exploring the intersection of genetics research and AI.
A better DNA material for genetic medicine
With its circular single-stranded DNA molecules, MIT spinout Kano Therapeutics plans to make gene and cell therapies safer and more effective.
Alternate proteins from the same gene contribute differently to health and rare disease
New findings may help researchers identify genetic mutations that contribute to rare diseases, by studying when and how single genes produce multiple versions of proteins.
A new way to understand and predict gene splicing
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.
Solar energy startup Active Surfaces wins inaugural PITCH.nano competition
Twelve START.nano companies competed for the grand prize of nanoBucks to be used at MIT.nano’s facilities.
In a surprising discovery, scientists find tiny loops in the genomes of dividing cells
Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide.
A new system can dial expression of synthetic genes up or down
The promoter editing system could be used to fine-tune gene therapy or to more efficiently reprogram cells for therapeutic use.
A more precise way to edit the genome
MIT researchers have dramatically lowered the error rate of prime editing, a technique that holds potential for treating many genetic disorders.
This MIT spinout is taking biomolecule storage out of the freezer
Cache DNA has developed technologies that can preserve biomolecules at room temperature to make storing and transporting samples less expensive and more reliable.
Study explains how a rare gene variant contributes to Alzheimer’s disease
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.