New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
Drug makes tumors more susceptible to chemo
Compound that knocks out a DNA repair pathway enhances cisplatin treatment and helps prevent drug-resistance.
A “biomultimeter” lets scientists measure RNA and protein production in real-time
Fluorescent tagging system can expedite the process of designing genes and personalizing medicine.
The evolving definition of a gene
Professor Gerald Fink, a pioneer in the field of genetics, delivers the annual Killian Lecture.
Academic institutions grant commercial license for CRISPR-based SHERLOCK diagnostic technology in developed world
Rights are protected for broad use in developing world and for public health needs.
An easier way to engineer plants
MIT-led team uses nanoparticles to deliver genes into plant chloroplasts.
Why too much DNA repair can injure tissue
Overactive repair system promotes cell death following DNA damage by certain toxins, study shows.
Biologists answer fundamental question about cell size
The need to produce just the right amount of protein is behind the striking uniformity of sizes.
Scientists engineer new CRISPR platform for DNA targeting
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
Revising the textbook on introns
Whitehead Institute researchers uncover a group of introns in yeast that possess surprising stability and function.
DNA design that anyone can do
Computer program can translate a free-form 2-D drawing into a DNA structure.
Engineering "capture compounds" to probe cell growth
Researchers develop a method to investigate how bacteria respond to starvation and to identify which proteins bind to the “magic spot” — ppGpp.
Tracking the footprints of protein synthesis
Researchers refine a method to quantify protein production, show that the precision with which bacteria and eukaryotes tune their gene expression is remarkably similar.
Team invents method to shrink objects to the nanoscale
It’s not quite the Ant-Man suit, but the system produces 3-D structures one thousandth the size of the originals.
The long and short of CDK12
A new study linking RNA processing to DNA repair may open new avenues to cancer therapy.