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Diagnostics

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Photo of Sangeeta Bhatia standing in a lab

Faster tracking of treatment responses

Biological sensors developed by MIT spinout Glympse Bio could help clinicians make decisions for individual patients.

February 2, 2021

MIT engineers have designed nanoparticle sensors that can diagnose lung diseases. If a disease-associated protein is present in the lungs, the protein cleaves a gaseous molecule from the nanoparticle, and this gas can be detected in the patient’s breath.

Exhaled biomarkers can reveal lung disease

Specialized nanoparticles create a “breath signal” that could be used to diagnose pneumonia and other infectious or genetic diseases.

July 20, 2020

3M is collaborating with the lab of MIT Associate Professor Hadley Sikes to jointly develop a rapid Covid-19 test. Here, 3M Covid-19 test team members work in a pilot lab facility.

MIT team collaborates with 3M to develop rapid Covid-19 test

Company working with Sikes Lab to test feasibility of low-cost diagnostic that could be manufactured by the millions each day.

July 14, 2020

Hadley Sikes, who recently earned tenure in MIT’s Department of Chemical Engineering, devotes much of her lab’s effort to devising inexpensive, highly sensitive tests for diseases such as malaria, tuberculosis, and cancer.

Making an impact through chemical engineering

Hadley Sikes designs simple-to-use diagnostic devices that could benefit patients around the world.

May 18, 2020

Photograph of the microwell CARMEN chip.

CRISPR-based diagnostic chips perform thousands of tests simultaneously to detect viruses

Diagnostic platform CARMEN combines microfluidics with CRISPR-based detection technology SHERLOCK, and could one day be used for public health efforts.

April 29, 2020

SMART Antimicrobial Resistance Interdisciplinary Research Group and Low Energy Electronic Systems researchers (l-r) Hadley Sikes, Jia Huan, Tonio Buonassisi, and Isaac Siyu Tian optimize materials used in rapid protein tests.

3 Questions: Hadley Sikes on searching for a Covid-19 protein test

Chemical engineer aims to create a test that can work in 10 minutes and doesn’t require specialized instruments or laboratory infrastructure.

April 17, 2020

McGovern Institute scientists Jonathan Gootenberg (left) and Omar Abuddayeh in the lab

3 Questions: How Covid-19 tests work and why they’re in short supply

MIT scientists Omar Abudayyeh and Jonathan Gootenberg explain the current state of Covid-19 testing, and how a CRISPR tool may help solve the supply problem.

April 10, 2020

MIT engineers have developed nanoparticles that can be delivered to the lungs, where tumor-associated proteases cut peptides on the surface of the particles, releasing reporter molecules. Those reporters can be detected by a urine test.

New sensors could offer early detection of lung tumors

Study shows that a simple urine test can reveal the presence of lung cancer in mice.

April 1, 2020

American Physical Society honorees (left to right): Richard Milner and Pablo Jarillo-Herrero, professors of physics, and James Collins, professor of biological engineering.

American Physical Society honors three MIT professors for physics research

James Collins, Pablo Jarillo-Herrero, and Richard Milner have won top prizes for their work.

October 24, 2019

MIT engineers created a DNA-acrylamide gel that can be degraded by DNA-editing enzymes. At right, the gel is broken down after two hours of exposure to a DNA "trigger sequence." At left, the gel is exposed to DNA that doesn't contain the trigger sequence, so it remains intact.

Using CRISPR to program gels with new functions

Smart materials change properties in response to specific DNA sequences; could be used in a variety of devices.

August 22, 2019

MIT researchers have developed a noninvasive hydration sensor that is based on the same technology as MRI, but, unlike MRI scanners, it can fit in a doctor’s office.

Hydration sensor could improve dialysis

Noninvasive device could benefit patients with kidney disease, congestive heart failure, or dehydration.

July 24, 2019

Researchers test the paper diagnostic.

Detecting dengue, Zika, and chikangunya within minutes

MIT spinoff is changing the way mosquito-borne illnesses are diagnosed and aims to influence how public health officials react to disease outbreaks.

November 21, 2018

MIT engineers have designed an ingestible sensor equipped with bacteria programmed to sense environmental conditions and relay the information to an electronic circuit.

Ingestible “bacteria on a chip” could help diagnose disease

Ultra-low-power sensors carrying genetically engineered bacteria can detect gastric bleeding.

May 24, 2018

Jose Gomez-Marquez, co-director of MIT’s Little Devices Lab, holds a sheet of paper diagnostic blocks, which can be easily printed and then combined in various ways to create customized diagnostic devices.

Plug-and-play diagnostic devices

Modular blocks could enable labs around the world to cheaply and easily build their own diagnostics.

May 16, 2018

A new study, performed at MIT Medical, shows that most parents were able to successfully perform the Streptococcus (“strep throat”) test on their children.

Home strep test could save time and money

Study at MIT Medical finds most parents are capable of performing the test.

May 10, 2017