Brain and cognitive sciences

Using a new kind of microscope that closely tracks every movement, researchers seeking to study how organisms coordinate movement behaviors compiled a compendium of 100 reference postures that encompass the range of typical C. elegans poses.

How worms move: Dopamine helps nematodes coordinate motor behaviors

To spy on worms for days on end, Picower Institute scientists invent a new open-source microscopy platform.

June 30, 2020

Photo shows the device the team developed. The tube at top is connected to a supply of the precursor material, sodium nitrite, which then passes through a channel in the fiber at the bottom and into the body, which also contains the electrodes to stimulate the release of nitric oxide. The electrodes are connected through the four-pin connector on the left.

Producing a gaseous messenger molecule inside the body, on demand

Method could shed light on nitric oxide’s role in the neural, circulatory, and immune systems.

June 29, 2020

Using a new calcium indicator that accumulates in the cell bodies of neurons (boxes at right), MIT neuroscientists are able to more accurately image neuron activity. Traditional calcium indicators (boxes at left) can generate crosstalk that blurs the images.

A focused approach to imaging neural activity in the brain

New molecule for imaging calcium in neurons reduces crosstalk from neighboring neurons.

June 26, 2020

Researchers use skeletal keypoint data to match the movements of musicians with the tempo of their part, allowing listeners to isolate similar-sounding instruments.

Identifying a melody by studying a musician’s body language

Music gesture artificial intelligence tool developed at the MIT-IBM Watson AI Lab uses body movements to isolate the sounds of individual instruments.

June 25, 2020

When keeping track of location a particular region of the brain, the lateral septum, pays special attention to where the reward is located, compared to another region, the hippocampus, that tracks location without that same bias.

Like a treasure map, brain region emphasizes reward location

The lateral septum encodes spatial information with a special emphasis on where the reward lies.

June 23, 2020

Researchers present at the MIT-Takeda launch event earlier this year.

MIT-Takeda program launches

Research projects will harness the power of artificial intelligence to positively impact human health.

June 18, 2020

An MIT-led research team has discovered evidence that a classic visual illusion called simultaneous brightness contrast, such as the one seen here, relies on brightness estimation that takes place in the retina, not the brain’s visual cortex. In this image, the two small discs appear to have different brightness despite having identical luminance.

Study sheds light on a classic visual illusion

Neuroscientists delve into how background brightness influences our perception of an object.

June 16, 2020

In Alzheimer's disease, the blood-brain barrier can become disrupted by the accumulation of amyloid protein, especially in people who carry a genetic variant called APOE4. This 3D rendering of an APOE4-carrying engineered blood vessel shows heavy accumulation of amyloid protein (green).

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

MIT researchers pinpoint mechanism and demonstrate that drugs could help.

June 15, 2020

MIT has long been a leader in sharing its research, teaching, and scholarship openly with the world.

MIT, guided by open access principles, ends Elsevier negotiations

Institute ends negotiations for a new journals contract in the absence of a proposal aligning with the MIT Framework for Publisher Contracts.

June 11, 2020

A set of images documents one participant through multiple interactions with MIT's "Your Baby the Physicist" study. The study is one of many now made more easily accessible to participants through the new Children Helping Science collaborative.

Serious science at home

Children Helping Science, co-led by Professor Laura Schulz, brings research to families, and families to research.

June 9, 2020

Researchers are studying the role of the immune system molecule IL-6 in Huntington's disease, which leads to neurodegeneration in a region of the brain called the striatum. In this figure from a prior study, green staining highlights Stat3 in the striatum. Stat3 is a major transducer of IL-6 signaling.

Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

June 8, 2020

A new algorithm, called the Fast Loaded Dice Roller (FLDR), simulates the roll of dice to produce random integers. The dice, in this case, could have any number of sides, and they are “loaded,” or weighted, to make some sides more likely to come up than others.

Algorithm quickly simulates a roll of loaded dice

Approach for generating numbers at random may help analyses of complex systems, from Earth’s climate to financial markets.

May 28, 2020

Students participating in MIT Quest for Intelligence-funded UROP projects include: (clockwise from top left) Alon Kosowsky-Sachs, Isaac Wolverton, Kuan Wei Huang, and Karen Gu.

Undergraduates develop next-generation intelligence tools

UROP students explore applications in robotics, health care, language understanding, and nuclear engineering.

May 26, 2020

MIT scientists have identified a potential new strategy for treating Fragile X syndrome, a disorder that is the leading heritable cause of intellectual disability and autism. The team includes, from left–right: Amanda Coranado, Arnold Heynen, Mark Bear, Rebecca Senter, Laura Stoppel, and Patrick McCamphill.

Scientists find a new way to reverse symptoms of Fragile X

Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism.

May 20, 2020

Clockwise from upper left: Angela Belcher, Bruce Walker, Jianzhu Chen, Feng Zhang, Siqi Zheng, and Lee Gehrke

Six from MIT awarded research funding to address Covid-19

Multi-institutional MassCPR initiative announces more than $16.5 million to support 62 Boston-area projects.

May 19, 2020

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