In an effort to better understand how protein language models (PLMs) think and better judge their reliability, MIT researchers applied a tool called sparse autoencoders, which can be used to make large language models more interpretable. The findings “may help scientists better understand how PLMs come to certain conclusions and increase researchers’ trust in them," writes Andrea Luis for The Scientist.
Prof. Linda Griffith speaks with Nature reporter Cassandra Willyard about her work developing lab-made organoids to help study the root causes of endometriosis. Griffith has been working to develop “a model of abnormal endometrial tissue that the researchers can use to test therapies for the condition,” writes Willyard. “Because blood vessels are crucial to maintaining this tissue, Griffith knew she wanted to include them. To do this, she and her colleagues placed the organoid on a microfluidic chip surrounded by cells that form blood vessels.”
Beth Pollack, a research scientist in the Department of Biological Engineering, speaks with The Guardian’s Science Weekly hosts Madeleine Finaly and Ian Sample about her research on chronic fatigue syndrome (MF CFS) and other chronic illnesses. “There are a number of interesting treatments addressing the different aspects of immune disfunction with different immunomodulators,” says Pollack.
Using generative AI, researchers at MT have designed new antibiotics to combat MRSA and gonorrhea, reports James Gallagher for the BBC. "We're excited because we show that generative AI can be used to design completely new antibiotics," says Prof. James Collins. "AI can enable us to come up with molecules, cheaply and quickly and in this way, expand our arsenal, and really give us a leg up in the battle of our wits against the genes of superbugs."
Strand Therapeutics, co-founded Jake Becraft PhD '19, has developed a programmable drug that could one day shrink tumors in cancer patients, reports Amy Feldman for Forbes. “It shocked even us,” says Becraft. “You hope something happens, but you don’t expect to see a huge response because these patients have already proven to have cancers so resistant to treatment.”
Researchers at MIT are working to advance our understanding of acute Lyme disease and long Covid, reports Brianna Abbott for The Wall Street Journal. “What we’re trying to do is measure everything,” said Principal Scientist Michal Caspi Tal. “I want to find a way to give people hope.”
Wall Street Journal reporter Dominique Mosbergen spotlights how Prof. James Collins and his lab have built their “own algorithms to trawl chemical databases, such as those of existing pharmaceutical drugs, for potential antibacterial compounds.” Collins’ His lab is “also experimenting with using generative AI to design completely new molecules that could kill bacteria,” writes Mosbergen.
Researchers from MIT and other institutions have uncovered new pathways, along with identifying genes, that may contribute to the development of a new class of drugs to treat Alzheimer’s disease, reports John R. Ellement for The Boston Globe. “The drugs currently approved to treat Alzheimer’s have not been as successful as hoped,” Ellement explains. “Those drugs tend to target amyloid plaques in the brain, but the new research suggests other areas to target.”
Tech Crunch reporter Tim De Chant spotlights Fieldstone Bio, an MIT startup that turns microbes into sensors to support agricultural and national security efforts. “Each strain is tailored to sense a particular compound, such as nitrogen on a farm field or TNT residue from a landmine,” explains De Chant. “After the microbes have some time to sense their environment — several hours to days, depending on the target — the company will have another drone snap photos of the area.”
Materials World reporter Sarah Morgan spotlights how MIT researchers have “combined the waterproof stickiness of mussel-inspired polymers with the germ-fighting properties of mucus-derived proteins, mucins, to form a cross-linking gel that strongly adheres to surfaces.” The new adhesive could be used to coat medical implants to prevent infection and bacteria build-up. Postdoc George Degen explains: “We demonstrate adhesion to wet tissue and metal-oxide surfaces, important substrates for biomedical applications. Moreover, our mucin-derived hydrogels discourage the formation of bacterial biofilms, raising the possibility of antifouling coatings.”
Syntis Bio, a biopharmaceutical company co-founded by Prof. Giovanni Traverso and Prof. Robert Langer, is developing a daily obesity pill that mimics the effects of gastric bypass, reports Emily Mullin for Wired. “This material is something you would take as a capsule or liquid, but the next day it's gone because of the natural turnover of our mucosal surface in the GI tract,” says Traverso.
MIT researchers have developed a method to grow artificial muscle tissue that twitches and flexes in multiple, coordinated directions, and could be useful for building “biohybrid” robots, reports Andrew Corselli for Tech Briefs. Prof. Ritu Raman explains that her lab is focused on creating “artificial muscle tissues that can be used to understand and treat muscle diseases that impact healthy human mobility,” and making “safe muscle-powered robots that can perform complex tasks in dangerous environments that are not suitable for humans.”
MIT researchers have developed a new method to grow artificial muscles for soft robots that can move in multiple directions, mimicking the iris of an eye, reports Mrigakshi Dixit for Interesting Engineering. The researchers developed a new technique called “stamping” to create “an artificial iris-like structure,” Dixit explains. “For this, they 3D-printed a tiny stamp, patterned with microscopic grooves. This stamp is then pressed into a soft hydrogel to create a blueprint for muscle growth.”
Ministry of Supply, a clothing brand founded by MIT alumni, has developed a machine-washable, heated jacket, reports Rebecca Barker for Fast Company. “The issue with a lot of heated garments is that they want you to know that they’re heated garments,” says co-founder Gihan Amarasiriwardena '11. “The controller is on the outside, for example, they’re often times made out of kind of cheap shell material, so it doesn’t look as high quality. We think of the heating system as a secondary element, because we think the design of the garment can stand on its own.”
WCVB-TV's Chronicle spotlights Prof. Linda Griffith, “a forerunner in the field of biological engineering,” for her research investigating endometriosis and breaking the stigma around menstruation. Griffith founded the MIT Center for Gynepathology Research in 2009 and “one of their objectives is to help develop ways of staging endometriosis, similar to how cancer is characterized.” Griffith notes that by focusing on menstruation and making it a science, “I think we will really change the game for women.