AI algorithm enables tracking of vital white matter pathways
Opening a new window on the brainstem, a new tool reliably and finely resolves distinct nerve bundles in live diffusion MRI scans, revealing signs of injury or disease.
Chemists determine the structure of the fuzzy coat that surrounds Tau proteins
Learning more about this structure could help scientists find ways to block Tau from forming tangles in the brain of Alzheimer’s patients.
Study suggests 40Hz sensory stimulation may benefit some Alzheimer’s patients for years
Five volunteers received 40Hz stimulation for around two years after an early-stage clinical study. Those with late-onset Alzheimer’s performed better on assessments than Alzheimer’s patients outside the trial.
MIT researchers invent new human brain model to enable disease research, drug discovery
Cultured from induced pluripotent stem cells, “miBrains” integrate all major brain cell types and model brain structures, cellular interactions, activity, and pathological features.
Immune-informed brain aging research offers new treatment possibilities, speakers say
Speakers at MIT’s Aging Brain Initiative symposium described how immune system factors during aging contribute to Alzheimer’s, Parkinson’s and other conditions. The field is leveraging that knowledge to develop new therapies.
Study explains how a rare gene variant contributes to Alzheimer’s disease
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.
Alzheimer’s erodes brain cells’ control of gene expression, undermining function, cognition
Study of 3.5 million cells from more than 100 human brains finds Alzheimer’s progression — and resilience to disease — depends on preserving epigenomic stability.
Imaging tech promises deepest looks yet into living brain tissue at single-cell resolution
By combining several cutting-edge imaging technologies, a new microscope system could enable unprecedentedly deep and precise visualization of metabolic and neuronal activity, potentially even in humans.
Scientists discover potential new targets for Alzheimer’s drugs
Pathways involved in DNA repair and other cellular functions could contribute to the development of Alzheimer’s.
A brief history of expansion microscopy
Since an MIT team introduced expansion microscopy in 2015, the technique has powered the science behind kidney disease, plant seeds, the microbiome, Alzheimer’s, viruses, and more.
Evidence that 40Hz gamma stimulation promotes brain health is expanding
A decade of studies provide a growing evidence base that increasing the power of the brain’s gamma rhythms could help fight Alzheimer’s, and perhaps other neurological diseases.
Designing better ways to deliver drugs
Graduate student and MathWorks Fellow Louis DeRidder is developing a device to make chemotherapy dosing more accurate for individual patients.
Seeing more in expansion microscopy
New methods light up lipid membranes and let researchers see sets of proteins inside cells with high resolution.
New open-source tool helps to detangle the brain
The software tool NeuroTrALE is designed to quickly and efficiently process large amounts of brain imaging data semi-automatically.
Study reveals ways in which 40Hz sensory stimulation may preserve brain’s “white matter”
Gamma frequency light and sound stimulation preserves myelination in mouse models and reveals molecular mechanisms that may underlie the benefit.