Five volunteers received 40Hz stimulation for around two years after an early-stage clinical study. Those with late-onset Alzheimer’s performed better on assessments than Alzheimer’s patients outside the trial.
Cultured from induced pluripotent stem cells, “miBrains” integrate all major brain cell types and model brain structures, cellular interactions, activity, and pathological features.
Speakers at MIT’s Aging Brain Initiative symposium described how immune system factors during aging contribute to Alzheimer’s, Parkinson’s and other conditions. The field is leveraging that knowledge to develop new therapies.
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.
Study of 3.5 million cells from more than 100 human brains finds Alzheimer’s progression — and resilience to disease — depends on preserving epigenomic stability.
By combining several cutting-edge imaging technologies, a new microscope system could enable unprecedentedly deep and precise visualization of metabolic and neuronal activity, potentially even in humans.
Pathways involved in DNA repair and other cellular functions could contribute to the development of Alzheimer’s.
Since an MIT team introduced expansion microscopy in 2015, the technique has powered the science behind kidney disease, plant seeds, the microbiome, Alzheimer’s, viruses, and more.
A decade of studies provide a growing evidence base that increasing the power of the brain’s gamma rhythms could help fight Alzheimer’s, and perhaps other neurological diseases.
Graduate student and MathWorks Fellow Louis DeRidder is developing a device to make chemotherapy dosing more accurate for individual patients.
New methods light up lipid membranes and let researchers see sets of proteins inside cells with high resolution.
The software tool NeuroTrALE is designed to quickly and efficiently process large amounts of brain imaging data semi-automatically.
Gamma frequency light and sound stimulation preserves myelination in mouse models and reveals molecular mechanisms that may underlie the benefit.
Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.
PhD student Xinyi Zhang is developing computational tools for analyzing cells in the age of multimodal data.