New insights into a hidden process that protects cells from harmful mutations
Research reveals how cells may activate a compensation system that can reduce the effects of harmful genetic mutations. This could inform gene therapy development.
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Locally produced proteins help mitochondria function
Researchers developed an approach to study where proteins get made, and characterized proteins produced near mitochondria, gaining potential insights into mitochondrial function and disease.
Mapping cells in time and space: New tool reveals a detailed history of tumor growth
Researchers developed a tool to recreate cells’ family trees. Comparing cells’ lineages and locations within a tumor provided insights into factors shaping tumor growth.
New method combines imaging and sequencing to study gene function in intact tissue
The approach collects multiple types of imaging and sequencing data from the same cells, leading to new insights into mouse liver biology.
MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures
With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly.
CHARMed collaboration creates a potent therapy candidate for fatal prion diseases
A new gene-silencing tool shows promise as a future therapy against prion diseases and paves the way for new approaches to treating disease.
Blood cell family trees trace how production changes with aging
Jonathan Weissman and collaborators developed a tool to reconstruct human cell family trees, revealing how blood cell production changes in old age.
A cool path to disease deceleration
MIT PhD student Kathrin Kajderowicz is studying how hibernation-like states could pave the way for new hypothermic therapies.
Focus on function helps identify the changes that made us human
A new approach for identifying significant differences in gene use between closely-related species provides insights into human evolution.
Six from MIT awarded 2023 Paul and Daisy Soros Fellowships for New Americans
Fellowship funds graduate studies for outstanding immigrants and children of immigrants.
Uncovering how cells control their protein output
Gene-Wei Li investigates the rules that cells use to maintain the correct ratio of the proteins they need to survive.
A “door” into the mitochondrial membrane
Study finds the protein MTCH2 is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and MTCH2-linked conditions.
Robert Langer wins BBVA Foundation Frontiers of Knowledge Award
Institute Professor honored for groundbreaking work in nucleic acid delivery and nanoparticles.
New CRISPR-based map ties every human gene to its function
Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.
Tracing a cancer’s family tree to its roots reveals how tumors grow
Family trees of lung cancer cells reveal how cancer evolves from its earliest stages to an aggressive form capable of spreading throughout the body.