New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.
A “biomultimeter” lets scientists measure RNA and protein production in real-time
Fluorescent tagging system can expedite the process of designing genes and personalizing medicine.
Earliest life may have arisen in ponds, not oceans
Study finds shallow bodies of water were probably more suitable for Earth’s first life forms.
The evolving definition of a gene
Professor Gerald Fink, a pioneer in the field of genetics, delivers the annual Killian Lecture.
Academic institutions grant commercial license for CRISPR-based SHERLOCK diagnostic technology in developed world
Rights are protected for broad use in developing world and for public health needs.
Tissue model reveals how RNA will act on the liver
Studies could speed the development of new treatments for liver disease.
Scientists engineer new CRISPR platform for DNA targeting
CRISPR team harnesses new Cas12b enzyme for use in eukaryotic cells, adding to the CRISPR toolbox.
Engineers create an inhalable form of messenger RNA
Patients with lung disease could find relief by breathing in messenger RNA molecules.
Tracking the footprints of protein synthesis
Researchers refine a method to quantify protein production, show that the precision with which bacteria and eukaryotes tune their gene expression is remarkably similar.
Measuring cancer cell “fitness” reveals drug susceptibility
Together, cell growth rate and gene expression shed light on why some tumor cells survive treatment.
New CRISPR tool opens up more of the genome for editing
Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.
This RNA-based technique could make gene therapy more effective
Biological engineers design RNA circuits that enable precise control over the dose of therapeutic protein a patient receives.
Ankur Jain joins Whitehead Institute and the Department of Biology
Biophysicist will investigate the biology of RNA aggregation.
Decoding RNA-protein interactions
Scientists leverage one step, unbiased method to characterize the binding preferences of more than 70 human RNA-binding proteins.
Network of diverse noncoding RNAs acts in the brain
Scientists identify the first known network consisting of three types of regulatory RNAs.