Startups

Prof. David Sontag, Monica Agrawal PhD '23, Luke Murray SM '22, and Divya Gopinath '19, MEng '20 co-founded Layer Health - an AI healthcare startup that is applying large language models (LLMs) to help clinicians with medical chart reviews and data abstraction, reports Seth Joseph for Forbes. “The same chart review problem we’re solving with our clinical registry module is faced by clinicians at the point of care,” says Sontag. “For example, one of our next modules will focus on real-time clinical decision support to help automate clinical care pathways, leading to more reliable, high-quality care."

24M, an MIT startup, has been named to Fast Company’s list of the most innovative companies in the energy space for 2025, reports Alex Pasternack. The company “has been developing a portfolio of battery technologies designed to make batteries that are safer, cheaper, cleaner, and longer-lasting,” explains Pasternack. “Its technologies include a semisolid electrode for conventional and novel battery chemistries, which gives the battery more energy density and requires fewer materials, and a unique separator that monitors the cell and helps prevent the aberrations that cause shorts and fires.” 

Venti Technologies – a company co-founded by MIT researchers and alumni – has been named one of the most innovative companies in the Asia-Pacific region for Fast Company’s 2025 roundup of top companies, reports Katerina Barton. The company focuses “on autonomous technologies for industrial use—specifically in low-speed environments like ports, airports, and warehouses,” explains Barton. “The company’s suite of special-purpose algorithms is designed to optimize cargo container transportation and works with a wide range of vehicles, allowing the AI-enabled technology to move varying weight loads and distances through complex spaces and changing routes.” 

Newsha Ghaeli PhD '17, co-founder of BioBot Analytics, speaks with GBH Morning Edition host Mark Herz about the company’s role in helping public health officials during the Covid-19 pandemic. “When we started the company, the vision was really that wastewater is a source of very important source on human health,” says Ghaeli. 

New Yorker reporter Brent Crane spotlights Quaise Energy, an MIT geothermal energy startup founded by Carlos Araque BS '01, MS '02. Crane explains that central to Quaise’s system is the gyrotron, a tubular device that “works like a very, very powerful microwave, emitting ‘millimeter waves’ that would vaporize your vegetables; they can generate temperatures of a hundred million degrees Celsius.” Crane notes that: “About a decade ago, Paul Woskov, an MIT research engineer, showed that the technology could be used for ‘energy drilling’ without a physical bit. Quaise’s scientists propose that the heat of a gyrotron could stabilize tunnel walls by vitrifying them into glass.” 

Bloomberg reporter Robb Mandelbaum spotlights how the Martin Trust Center for MIT Entrepreneurship has developed a new AI JetPack to help students accelerate the entrepreneurial process. “Our mission at the Trust Center is to advance the field of innovation-driven entrepreneurship everywhere,” Paul Cheek, executive director of the Martin Trust Center. “We can’t do it with intuition or by throwing stuff against the wall. We have to practice entrepreneurship in a rigorous, systematic way that increases the odds of success.”

Principal Research Scientist Andrew McAfee co-founded Workhelix, a “tech-enabled service startup that works with enterprises to better understand and monitor AI automation at their companies,” reports Rebecca Szkutak for Tech Crunch. “Workhelix breaks down a company’s employee positions into specific job functions and tasks and scores each task for its suitability for AI adoption,” explains Szkutak. “This helps companies build roadmaps for how and where to adopt AI and gives enterprises a way to monitor if the AI they adopted is working.” 

Boston Globe reporter Scott Kirsner spotlights Lybra Bio, an MIT startup that is developing a “patch to treat skin conditions like psoriasis and alopecia areata, which causes hair loss.” Kirsner notes that Lybra “envisions a patch that could deliver drugs to precisely where they’re needed on the skin — like the scalp, in the case of alopecia.”

Varun Mohan '17, SM '17 and Douglas Chen '17 co-founded Codeium, an AI-powered coding startup designed to help users write code in a faster and more efficient manner, reports Marina Temkin for TechCrunch. “Codeium tries to distinguish itself from competitors by targeting companies rather than individual developers,” writes Temkin. 

Nature reporter Elizabeth Gibney spotlights QuEra, an MIT spinout that uses atoms and lasers to encode quantum bits or “qubits.” Gibney notes that in the QuEra system, “physicists trap an array of rubidium atoms using laser light and store quantum information in the energy levels of their electrons.”

Evan Ehrenberg PhD '16 co-founded Waterlily, a company that “uses artificial intelligence to predict a family’s future long-term care needs and costs” with the right care and financial planning, reports Mary Ann Azevedo for TechCrunch. “Ehrenberg — who had previously founded and sold Clara Health — helped with early research and was struck by the industry’s response,” writes Azevedo. “Curious, he tested the platform and was shocked by his long-term care predictions — so much so that he changed his diet, hired a personal trainer, and updated his financial plans.” 

Georgina Campbell Flatter SM '11 has been named the chief executive of Greentown Labs, the “nation’s largest clean-tech incubator,” reports Jon Chesto for The Boston Globe. “This is a pretty critical time for energy and climate, and we all need to lean in,” says Flatter. 

Former postdoctoral associate Wen Shuhao and postdoctoral fellows Ma Jian and Lai Lipeng co-founded Xtalpi, a biotech startup that “uses AI and quantum physics-based calculations to find suitable structures that are fit for drug making,” reports Zinnia Lee for Forbes. The company plans to expand their technology to other industries such as solar panels and electric vehicle batteries. 

Prof. Desirée Plata speaks with C&EN reporter Prachi Patel about her work “trying to make our chemical processes and industries compatible with human and ecological health.” Says Plata of what she is most proud of in her work: “As professors, we produce papers and patents, but people are the most important thing we produce. The faculty of the world are training the next generation of researchers. There’s a perception right now that AI is going to solve all of our problems, but it cannot without good physical science information. We need a trained workforce. We need patient chemists who want to solve important problems.”

Shiv Bhakta MBA '24, SM '24 and Richard Swartwout SM '18, PhD '21 co-founded Active Surfaces, a solar tech company that has developed “a new kind of solar collector so thin and flexible it can be attached to anything under the sun,” reports Hiawatha Bray for The Boston Globe. “The company prints solar cells onto a plastic sheet, using methods not too different from those used to print newspapers,” explains Bray. “The resulting cells can generate electric power nearly as efficiently as today’s heavy, thick silicon panels.”