School of Science

Cognito Therapeutics, an MIT startup co-founded by Prof. Li-Huei Tsai and Prof. Ed Boyden, has developed a headset that uses light and sound to slow the cognitive decline in Alzheimer’s patients, reports Emily Mullin for Wired. “Cognito’s headset, dubbed Spectris, delivers flashing lights and sounds through a pair of connected glasses and headphones to stimulate gamma waves in the brain” writes Mullin. “Different types of brain waves have different paces, or frequencies. Gamma waves are fast-frequency brain waves associated with thinking skills and memory, and people with Alzheimer’s are known to have fewer of these fast brain waves.”

Bingxu Liu PhD '23 speaks with Science reporter Christie Wilcox about his work  studying STING, an immune protein that plays a key role in defending the human body against viruses, bacteria, and tumors. “STING is actually one of the most promising cancer immunotherapy targets,” explains Wilcox. “If you activate the STING pathway, it triggers a very strong immune response. But when it’s too strong, it can actually kill your T cells. Initial evidence suggest that T cells die because of some ion impact. Which begs the question: Can we just use STING to activate some parts of the immune response, like interferon, but also block the ion flow [that’s harming T cells]?” 

Senior Research Scientist Lisa Barsotti speaks with MIT Technology Review reporter Sophia Chen about how she and her colleagues developed a new device that uses quantum squeezing to help the LIGO detectors identify more celestial events, such as black hole mergers and neutron star collisions. “With these latest squeezing innovations, installed last year, the collaboration expects to detect gravitational waves up to 65% more frequently than before,” Chen explains.

A new study by MIT researchers finds that an experimental Alzheimer’s treatment involving sound and light stimulation at a frequency of 40 Hz is associated with, “an increase in activity of the brain's own cleanup crew; the glymphatic system,” reports Pandora Dewan for Newsweek. The findings offer an, “exciting, non-invasive potential treatment option for patients with neurological disorders in the future,” Dewan notes.

MIT scientists have found that an experimental treatment for Alzheimer's disease involving sounds and flickering lights appears to “ramp up the brain’s waste disposal networks, which boosts the clearance of beta-amyloid and other toxic proteins that contribute to memory and concentration problems,” reports Clare Wilson for New Scientist. “Once we understand the mechanism, we can probably figure out how to further optimize this whole concept and improve the efficacy,” explains Prof. Li-Huei Tsai.

Prof. Feng Zhang has been named to STAT’s 2024 STATUS List, which highlights the leaders shaping the future of health and life sciences, reports Dialynn Dwyer for Boston.com. “Among the companies he’s co-founded is Editas Medicine, which as of late 2023 was now the official holder of patent rights to the CRISPR-Cas9 gene editing tool used in the sickle cell therapy Casgevy, and Aera Therapeutics, which in February 2023 raised $193 million in venture funding to develop protein nanoparticles as a way of delivering gene editing,” Dwyer writes.

Gizmodo reporter Isaac Schultz writes that MIT scientists have captured images of heat moving through a superfluid, a phenomenon that “may explain how heat moves through certain rare materials on Earth and deep in space.”  Schultz notes that the researchers believe their examination of heat flow in a superfluid “can be used to determine heat flow in high-temperature superconductors, or even in neutron stars, the roiling, ultra-dense relics of ordinary stars.”

For the first time, MIT physicists have successfully imaged how heat travels in a superfluid, known as a “second sound,” reports Darren Orf for Popular Mechanics. “While exotic superfluids may not fill up our lives (yet),” writes Orf, “understanding the properties of second wave movement could help questions regarding high-temperature superconductors (again, still at very low temperatures) or the messy physics that lie at the heart of neutron stars.”

Physics World reporter Tim Wogan spotlights how MIT physicists have developed a new technique for measuring the temperature of “second sound,” the movement of heat through a superfluid. “The work could help model a variety of scientifically interesting and poorly understood systems, including high temperature superconductors and neutron stars,” Wogan explains.

MIT has been named to the number two spot in Times Higher Education’s world reputation rankings, reports Times Higher Education. MIT is “dedicated to the teaching of science and technology. The sheer number of Nobel laureates affiliated with the institution – an impressive 101 – reveals the caliber of MIT graduates,” Times Higher Education notes. “Scientific discoveries and technological advances to come out of the college include the first chemical synthesis of penicillin, the development of radar, the discovery of quarks and the invention of magnetic core memory, which aided the development of digital computers.”

Prof. Ernest Moniz and his colleagues have designed a new consortium that plans to create an organized market for hydrogen, reports Llewellyn King for Forbes. This will allow hydrogen to become “a viable option in the pursuit of net-zero emissions,” writes King.

Prof. Erin Kara speaks with Quanta Magazine reporter Michael Greshko about her career as an observational astrophysicist and her work to better understand how black holes behave and reshape galaxies across the universe. “The thing that really got me excited about pursuing astronomy was the discovery aspect: It was just super thrilling to be the first person to look at light that was released from around a black hole a billion years ago,” says Kara.

Senior Lecturer Richard Price and his colleagues have scored a touchdown by uncovering the physics behind a spiral pass, “those perfect throws where the football leaves the player's hand and neatly spins as it arcs through the air,” reports NPR Short Wave host Regina Barber.

Researchers at MIT have discovered 18 supermassive black holes that “are tearing apart nearby stars in ‘oddball’ tidal disruption events,” reports Ava Berger for The Boston Globe. Graduate student Megan Masterson says, “the events are powerful tools to understand the most extreme parts of our universe. They happen about once every 50,000 years, and help scientists learn more about the supermassive black hole at the center of the Milky Way, and black holes in general.”

A more than $40 million investment to add advanced nano-fabrication equipment and capabilities to MIT.nano will significantly expand the center’s nanofabrication capabilities, reports Jon Chesto for The Boston Globe. The new equipment, which will also be available to scientists outside MIT, will allow “startups and students access to wafer-making equipment used by larger companies. These tools will allow its researchers to make prototypes of an array of microelectronic devices.”