Study explains how a rare gene variant contributes to Alzheimer’s disease
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.
“Bottlebrush” particles deliver big chemotherapy payloads directly to cancer cells
Outfitted with antibodies that guide them to the tumor site, the new nanoparticles could reduce the side effects of treatment.
Alzheimer’s erodes brain cells’ control of gene expression, undermining function, cognition
Study of 3.5 million cells from more than 100 human brains finds Alzheimer’s progression — and resilience to disease — depends on preserving epigenomic stability.
A comprehensive cellular-resolution map of brain activity
An international collaboration of neuroscientists, including MIT Professor Ila Fiete, developed a brain-wide map of decision-making at cellular resolution in mice.
Imaging tech promises deepest looks yet into living brain tissue at single-cell resolution
By combining several cutting-edge imaging technologies, a new microscope system could enable unprecedentedly deep and precise visualization of metabolic and neuronal activity, potentially even in humans.
A boost for the precision of genome editing
Researchers develop a fast-acting, cell-permeable protein system to control CRISPR-Cas9, reducing off-target effects and advancing gene therapy.
Researchers glimpse the inner workings of protein language models
A new approach can reveal the features AI models use to predict proteins that might make good drug or vaccine targets.
Using generative AI, researchers design compounds that can kill drug-resistant bacteria
The team used two different AI approaches to design novel antibiotics, including one that showed promise against MRSA.
How the brain distinguishes oozing fluids from solid objects
A new study finds parts of the brain’s visual cortex are specialized to analyze either solid objects or flowing materials like water or sand.
Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets
Combining powerful imaging, perturbational screening, and machine learning, researchers uncover new human host factors that alter Ebola’s ability to infect.
How to more efficiently study complex treatment interactions
A new approach for testing multiple treatment combinations at once could help scientists develop drugs for cancer or genetic disorders.
Implantable device could save diabetes patients from dangerously low blood sugar
The new implant carries a reservoir of glucagon that can be stored under the skin and deployed during an emergency — with no injections needed.
MIT chemists boost the efficiency of a key enzyme in photosynthesis
The enzyme, known as rubisco, helps plants and photosynthetic bacteria incorporate carbon dioxide into sugars.
MIT and Mass General Hospital researchers find disparities in organ acceptance
In an analysis of over 160,000 transplant candidates, researchers found that race is linked to how likely an organ offer is to be accepted on behalf of a patient.
Study: Babies’ poor vision may help organize visual brain pathways
MIT researchers found that low-quality visual input early in life may contribute to the development of key pathways in the brain’s visual system.