A team of researchers led by Prof. J. Christopher Love has developed a system to produce on-demand clinical-grade vaccines and drugs, writes Dr. Francis Collins on the NIH Director’s Blog. In addition to allowing on site production for hospitals the systems could also “produce biologic treatments specially tailored to attack the cancer of a particular individual,” suggests Collins.
Writing for STAT, Karen Weintraub spotlights Prof. J. Christopher Love’s work developing a new desktop drug manufacturing process that can produce thousands of doses of biopharmaceuticals on demand. “I think in the long run there’ll be an opportunity to think about manufacturing for patients in a new way,” says Love.
Boston Globe reporter Martin Finucane writes that MIT researchers have developed sensors that can track dopamine levels in the brain. The sensors could eventually be used to monitor “Parkinson’s patients who receive a treatment called deep brain stimulation,” Finucane explains, adding that the sensors could “help deliver the stimulation only when it’s needed.”
By analyzing thousands of human cells and creating a cellular map of human barrier tissue, MIT researchers have identified the mechanism that may cause chronic allergic inflammation in the sinus, according to Xinhua News Agency. The findings could have “implications on treatment of other chronic inflammatory diseases of barrier tissues, such as asthma, eczema, and inflammatory bowel disease.”
STAT reporter Orly Nadell Farber writes about a new study by MIT researchers that shows glaucoma might be caused by T-cells, an integral component of the human body’s immune system, attacking retinal cells. Farber explains that, “this discovery could unlock a critical new door for treatment options.”
A new study by MIT researchers provides evidence that glaucoma may be caused by an autoimmune disease, according to a HealthDay News piece published by UPI. “Further research will try to determine whether other parts of the immune system play a role in glaucoma, and whether autoimmunity is a factor in degenerative brain diseases.”
Boston Globe reporter Martin Finucane writes that MIT researchers have identified the region of the brain responsible for generating negative emotions. “The findings could help scientists better understand how some of the effects of depression and anxiety arise, and guide development of new treatments,” Finucane explains.
Prof. Amy Finkelstein speaks with WBUR’s Carey Goldberg about her study showing only a small amount of Medicare spending goes end-of-life care. Finkelstein explains, “there is very little Medicare spending on people with high probability of dying. And part of that is just that it's very, very hard to predict who is going to die.”
STAT reporter Orly Nadell Farber writes about a new study by Prof. Amy Finkelstein that challenges the widely held assumption that a large portion of Medicare spending goes towards end-of-life care. “We spend money on sick people — some of them die, some of them recover,” says Finkelstein. “Maybe some recover, in part, because of what we spent on them.”
STAT reporter Justin Chen writes about a new study that examines why patients with pancreatic cancer often experience significant weight loss. Prof. Matt Vander Heiden explains that the findings show, “pancreatic cancer patients clearly have a lot of tissue wasting and whether it’s good or bad, we can now say that it’s not necessarily bad at diagnosis.”
Boston Herald reporter Lindsay Kalter writes that MIT researchers have developed a wireless ingestible sensor that could one day be used to diagnose and treat disease. “The most exciting thing is that we can wirelessly control tiny implants even though they have no batteries at all,” says Prof. Fadel Adib.
A new study led by Prof. Li-Huei Tsai reveals more information about the possible link between Alzheimer’s disease and the gene variant APOE4, writes Martin Finucane for The Boston Globe. The researchers discovered that by editing the gene into the more common APOE3 variant, “they could eliminate the signs of Alzheimer’s in brain cells,” said Finucane.
Bucking conventional wisdom, research co-authored by Prof. Josh Tenenbaum shows that “picking up the subtleties of grammar in a a second language does not fade until well into the teens,” writes Dana G. Smith for Scientific American. “To become completely fluent, however, learning should start before the age of 10.”
MIT researchers have identified the brain circuit required for observational learning, reports Xinhua. According to the study, the area involved in evaluating social information is more active when witnessing an experience and “relays information about the experience” to the region important for processing emotions.
A new paper co-authored by Prof. Omer Yilmaz and Prof. David Sabatini found that fasting substantially “improves stem cells' ability to regenerate,” reports Xinhua. The researchers hope this finding could lead to new drug treatments that “stimulate regeneration without requiring patients to fast, which is difficult for most people.”