Prof. Li-Huei Tsai and Prof. Ed Boyden co-founded Cognito Therapeutics after their research found that gamma waves could help clear amyloid plaques, which are known to appear in Alzheimer’s patients, reports Ryan Cross for The Boston Globe. “It was the most surprising result I’ve ever got in my life,” says Tsai. “When we published our first paper, most people said, ‘I don’t believe it. This is too good to be true. How can something this simple have this kind of effect?’”
In an excerpt from “Your Brain on Art” published in Fast Company, Susan Magsamen and Ivy Ross spotlight Prof. Li-Huei Tsai research exploring whether gamma oscillations from light and sound could help ease Alzheimer’s symptoms. “Li-Huei believes that increased gamma oscillations in the brain engage many different systems and cell types,” write Magsamen and Ross. “Because of this, the gamma waves may help with amyloid removal.”
Researchers at MIT have found that those with an E4 variant display abnormalities in cholesterol metabolism, reports William A. Haseltine for Forbes. “The MIT team suggest that the disruption of cholesterol metabolism could be a fundamental reason why those with the E4 variant are more likely to develop Alzheimer’s disease symptoms,” writes Haseltine.
MIT scientists have found that silent synapses - a type of memory-forming synapse - are present in the adult brain, reports The Economist. The discovery of these silent synapses, explains Prof. Mark Harnett, “is a lever for us to get into understanding learning in adults and how potentially we can get access to make it not degrade over the course of aging or disease.”
An MIT research study suggests that those with the E4 variant of the APOE gene are more likely to develop Alzheimer’s symptoms, reports William A. Haseltine for Forbes. The variant “disrupts how fat molecules are processed in the brain,” writes Haseltine. “It appears that the disruption of these fat molecules could be the fundamental reason why those that contain the E4 variant are more likely to develop Alzheimer’s symptoms.”
Researchers at MIT have found that the brain can send a burst of noradrenaline when it requires you to pay attention to something crucial, reports Juandre for Popular Mechanics. “The MIT team discovered that one important function of noradrenaline, commonly known as norepinephrine, is to assist the brain in learning from unexpected results,” explains Juandre.
Writing for The Boston Globe, Prof. Li-Huei Tsai underscores the need for the Alzheimer’s research community to “acknowledge the gaps in the current approach to curing the disease and make significant changes in how science, technology, and industry work together to meet this challenge.” Tsai adds: “With a more expansive mode of thinking, we can bridge the old innovation gaps and cross new valleys of discovery to deliver meaningful progress toward the end of Alzheimer’s.”
MIT researchers have developed a new wearable device, called Dormio, that can be used to record and even guide a person’s dreams, reports Mashable. Dormio is aimed at providing “insights into how dreams work and their effect on various things like memory, emotion, creativity.”
Research scientist César Hidalgo speaks with Kara Miller of WGBH’s Innovation Hub about his work exploring collective memory and how society experiences generational forgetting. For things like popular songs “there is a period of up to five years when they are still in our communicative memory, we are still talking about it," Hidalgo explains. “After that they go into our cultural memory.”
Los Angeles Times reporter Melissa Healy writes that a new study by MIT researchers provides evidence that acoustic and visual stimulation could improve Alzheimer’s symptoms. “The study’s central finding — that inducing electrical synchrony touched off such a widespread range of effects — suggests there might be a single key lever that can preserve or restore order in brains made 'noisy' by age and disease,” Healy explains.
A study by MIT researchers shows that exposing patients to flashing light and pulsing sounds could reverse Alzheimer’s symptoms, reports Angus Chen for Scientific American. “This is the first time we’ve seen that this noninvasive stimulation can improve cognitive function,” says Prof. Li-Huei Tsai.
New York Times reporter Pam Belluck writes that MIT researchers have found exposure to a specific combination of light and sound could improve Alzheimer’s symptoms. “It’s stunning that the intervention had beneficial effects on so many different aspects of Alzheimer-like pathology,” said Dr. Lennart Mucke, director of the Gladstone Institute of Neurological Disease.
Scientific American reporter Gary Stix highlights a study by researchers from the MIT Media Lab that examines the “underlying dynamics of collective attention and memory, traced as a bi-exponential curve (a steep drop followed by a slow decline over time).”
Natasha Frost of Quartz speaks with graduate student Mostafa Mohsenvand about his work developing a new wearable device that could one day be used to help people with memory loss. Frost writes the device may help those suffering with Alzheimer’s by “making memories instantly accessible externally for those who may otherwise be unable to recall them.”
Quartz reporter Madis Kabash highlights how Media Lab researchers are developing a device, dubbed Mnemo, that automatically records and retrieves a person’s memories. The project team aims to “build a memory bank big enough to help people with memory loss,” explains Kabash.