Boston Herald reporter Rick Sobey writes that a new drug combination has shown potential in treating pancreatic cancer. “The trio drug combination is a CD40 agonist antibody, a PD-1 inhibitor and a TIGIT inhibitor. The researchers found that this combination led to pancreatic tumors shrinking in about 50% of the animals that were given this treatment,” writes Sobey.
Forbes reporters Amy Feldman and Aayushi Pratap spotlight Vicarious Surgical, a startup founded by MIT graduates that is developing a tiny robot paired with a VR headset for abdominal surgeries.
MIT researchers have developed a new type of stent based on kirigami, the Japanese art of folding and cutting paper, which is “designed to improve localized drug delivery for diseases that affect tubular organs such as the oesophagus and bowel,” writes Cynthia Keen for Physics World. “We view these approaches as having the capacity to transform the patient experience by reducing the need to take medications and thereby significantly improving drug adherence,” says Prof. Giovanni Traverso.
WHDH spotlights how MIT and Harvard researchers are creating wearable biosensors that could be used to detect Covid-19 in a person’s breath. “At the end of the day, what we wanted to do was basically to blend both to potentially produce a product that was more easily incentivized patients to both wear a mask and to get tested,” explains Luis Soenksen of the Abdul Latif Jameel Clinic for Machine Learning in Health.
A new sensor developed by MIT and Harvard researchers can be embedded in a face mask and used to alert the wearer if they have Covid-19, reports CBS Boston. “Small disposable sensors can diagnose the wearer of the mask within 90 minutes," reports CBS Boston. "The technology has been used before to detect Ebola and Zika, but now researchers are embedding it into face masks and lab coats as a new method to safeguard health care workers.”
Researchers from MIT and Harvard have developed a new sensor technology that can be embedded in a face mask to detect whether the wearer has Covid-19, reports Pranshu Verma for The Boston Globe. “We worked hard, sometimes bringing nonbiological equipment home and assembling devices manually,” says Luis Soenksen of the Abdul Latif Jameel Clinic for Machine Learning in Health. “It was definitely different from the usual lab infrastructure we’re used to working under, but everything we did has helped us ensure that the sensors would work in real-world pandemic conditions.”
Researchers from MIT and Harvard have developed a face mask outfitted with sensors that can detect if the wearer has Covid-19, reports Adele Peters for Fast Company. “If testing and sensing at a biological molecular level could be done in a format that can follow people around instead of people having to go to the clinic, maybe you can encourage people to get more testing done,” says Luis Soenksen, a Venture Builder at MIT’s Abdul Latif Jameel Clinic for Machine Learning in Health.
A recent review by MIT researchers finds that “only about 23% of machine learning studies in health care used multiple datasets to establish their results, compared to 80% in the adjacent field of computer vision, and 58% in natural language processing,” writes Casey Ross for STAT. “If the performance results are not reproduced in clinical care to the standard that was used during [a study], then we risk approving algorithms that we can’t trust,” says graduate student Matthew McDermott. “They may actually end up worsening patient care.”
Prof. Linda Griffith joins Terry Gross of NPR’s Fresh Air to discuss how studying endometriosis could help unlock some of the mysteries of tissue regeneration. "The regeneration of the endometrium is weirdly not studied as much as it should be," she says. "But it's fascinating because you get about a centimeter of growth of tissue that has beautifully formed blood vessels, an immune system, all of the structures of the tissue — over a period of about two weeks."
Wired reporter Max Levy spotlights Prof. Emery Brown and Earl Miller’s research examining how neurons in the brain operate as “consciousness emerges and recedes—and how doctors could better control it.” Levy writes that “Miller and Brown's work could make anesthesia safer, by allowing anesthesiologists who use the EEG to more precisely control drug dosages for people who are unconscious.”
Principal research scientist Leo Anthony Celi speaks with STAT reporter Katie Palmer about the importance of open data sharing in medical research, his new role as editor of PLOS Digital Health, and the challenges facing machine learning in medicine. “With digitization, we’re hoping each country will have an opportunity to create their own medical knowledge system,” says Celi.
Prof. Linda Griffith is on a mission to change the conversation about endometriosis “from one of women’s pain to one of biomarkers, genetics and molecular networks,” writes Rachel E. Gross for The New York Times. “The endometrium is inherently regenerative,” says Griffith. “So studying it, you’re studying a regenerative process — and how it goes wrong, in cases.”
Researchers from MIT and Brigham and Women’s Hospital have developed a robotic dog outfitted with a tablet that allows doctors to visit with emergency room patients remotely. “The robot could therefore avoid the risk of exposure to Covid-19 by healthcare professionals and help save the personal protective equipment necessary for each visit,” writes Ruggiero Corcella of Corriere della Sera.
A team from MIT has been named a co-winner of this year’s STAT Madness, a bracket-style competition for biomedical research. The team, led by visiting scientist Junwei Li and Prof. Gio Traverso, “developed a solution that, once inside the small intestine, undergoes a reaction and coats it with a temporary adhesive,” which could be used “to make drug delivery more efficient," reports Rebecca Sohn for STAT.
A new study by Prof. Jeffrey Harris finds that the extensive research invested in developing a vaccine for HIV has contributed to the successful development of Covid-19 vaccines, writes Derek Thompson for The Atlantic. Nearly 90 percent of COVID-19 vaccines that made it to clinical trials used technology that “could be traced back to prototypes tested in HIV vaccine trials,” Harris found.