Medicine

Writing for GBH, graduate students and alumni Jessica Chomik-Morales, Sarah Akaaboune, Mackenzie White '25, Celina Zhao '24, SM '25, spotlight the Dana-Farber mobile Mammogram Van. “The unit meets women where they live and work, offering care in the languages they speak,” they write. “By bringing screenings to neighborhoods with large Asian and other minority populations, the van shows how community-based, culturally responsive care can reduce disparities and improve access to critical health resources.” 

Researchers at MIT are working to advance our understanding of acute Lyme disease and long Covid, reports Brianna Abbott for The Wall Street Journal. “What we’re trying to do is measure everything,” said Principal Scientist Michal Caspi Tal. “I want to find a way to give people hope.”

Interesting Engineering reporter Saoirse Kerrigan spotlights a number of MIT research projects from the past decade. MIT has “long been a hub of innovation and ingenuity across multiple industries and disciplines,” writes Kerrigan. “Every year, the school’s best and brightest debut projects that push the boundaries of science and technology. From vehicles and furniture to exciting new breakthroughs in electricity generation, the school’s projects have tackled an impressive variety of subjects.” 

Prof. Giovanni Traverso speaks with WCVB about his research developing an ingestible robotic capsule capable of delivering an injection directly within the stomach. “Fifty percent of the population don’t take medication as prescribed. That’s incredible,” says Traverso. “So, if we can make a little dent, or hopefully a bigger dent, I think we can help a lot of folks out there.”  

Researchers at MIT have designed an implantable device that can be used to administer a dose of glucagon to protect Type 1 diabetics from hypoglycemia, reports Amir Khollam. “The device, about the size of a quarter, sits under the skin and releases a dose of glucagon when blood sugar levels dip too low,” explains Khollam. “It can be activated manually or triggered wirelessly by a sensor.” 

In a new paper, Prof. Giovanni Traverso and his colleagues highlight the results of a clinical trial that showed “a pill taken just once a week, gradually releasing medicine from within the stomach, can greatly simplify the drug schedule faced by schizophrenia patients,” writes Dennis Thompson for HealthDay News. “These final-stage clinical trial results are the product of more than 10 years of research by Traverso’s lab.” 

MIT researchers have developed Boltz-2, an AI algorithm “that unites protein folding and prediction of small-molecule binding affinity in one package,” reports Laura Howes for Chemical & Engineering News. “The researchers say their new AI model approaches the level of accuracy achieved by traditional computational chemistry—such as methods involving free-energy perturbation calculations—but much more quickly and cheaply,” explains Howes. 

Researchers at MIT and elsewhere have developed Boltz-2, an open-source generative AI model that can help researchers find new medicines faster, reports Alex Knapp for Forbes. The tool “can not only predict the structure of proteins, it can also predict its binding affinity–that is, how well a potential drug is able to interact with that protein,” explains Knapp. “This is crucial in the early stages of developing a new medicine.” 

Wall Street Journal reporter Dominique Mosbergen spotlights how Prof. James Collins and his lab have built their “own algorithms to trawl chemical databases, such as those of existing pharmaceutical drugs, for potential antibacterial compounds.” Collins’ His lab is “also experimenting with using generative AI to design completely new molecules that could kill bacteria,” writes Mosbergen. 

Researchers from MIT and other institutions have uncovered new pathways, along with identifying genes, that may contribute to the development of a new class of drugs to treat Alzheimer’s disease, reports John R. Ellement for The Boston Globe. “The drugs currently approved to treat Alzheimer’s have not been as successful as hoped,” Ellement explains. “Those drugs tend to target amyloid plaques in the brain, but the new research suggests other areas to target.” 

Emily Young '18, co-founder and CEO of MIT D-Lab spinout Moving Health, speaks with The World’s Jeremy Siegel about her startup’s commitment to transforming “maternal healthcare in rural Ghana, where access to ambulances is severely limited, by creating an emergency transportation network that uses motorized ambulances." Young discovered that “what rural communities needed most was transportation that could actually handle rough terrain while still being cost effective and easy to scale at a local level.”

Prof. Canan Dagdeviren speaks with NBC Boston  reporter Priscilla Casper about her work developing a wearable ultrasound scanner that can be used for early breast cancer detection, with the goal of empowering “women to monitor their own bodies, on their own time and in the comfort of their own home.” Dagdeviren explains that “our hope [is to] collect a lot of data and use AI to predict what will happen to breast tissue over time.”   

The new Hood Pediatric Innovation Hub, a cornerstone of MIT’s Health and Life Sciences Collaborative (MIT HEALS), is aimed at addressing “underinvestment in pediatric healthcare innovations,” reports Isabel Hart for the Boston Business Journal. Prof. Elazer Edelman, faculty lead for the hub, explains that: “We are trying to build a new culture providing innovation to those who have least access to it and will most benefit from it.”

Syntis Bio, a biopharmaceutical company co-founded by Prof. Giovanni Traverso and Prof. Robert Langer, is developing a daily obesity pill that mimics the effects of gastric bypass, reports Emily Mullin for Wired. “This material is something you would take as a capsule or liquid, but the next day it's gone because of the natural turnover of our mucosal surface in the GI tract,” says Traverso.

“AT MIT innovation ranges from awe-inspiring technology to down-to-earth creativity,” notes Chronicle during a visit to campus to peek behind the scenes at the innovations underway at the Institute. Classes taught by Prof. Erik Demaine are a “mix of rigorous math and creative collaboration,” host Anthony Everett explains, highlighting how Demaine’s work in computational origami has found its way into practical applications in such fields as medicine, architecture and space exploration. “I think origami provides a really powerful tool for making transformable shapes,” Demaine relates.