Researchers at the McGovern and Broad Institutes have developed a bacterial "nanosyringe" that can inject large proteins into specific cells in the body, which could lead to safer and more effective treatments for a variety of conditions, including cancer, reports Michael Le Page for New Scientist. “The fact that this can load a diversity of different payloads of different sizes makes it unique amongst protein delivery devices,” says graduate student Joseph Kreitz.
Ingrid Wickelgren at Scientific American highlights a new study from researchers at the McGovern and Broad Institutes, in which they used a bacterial ‘nanosyringe’ to inject large proteins into human cells. “The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells,” writes Wickelgren.
Aera Therapeutics, founded by Prof. Feng Zhang, is working to “debut a type of protein nanoparticle that it believes can be used to ferry all sorts of genetic medicines around the body,” reports Lisa Jarvis for Bloomberg.
Prof. Feng Zhang founded Aera Therapeutics, a startup working to deliver curative genetic medicine to hard-to-reach parts of the body, reports Ryan Cross for The Boston Globe. “If Aera’s approach works in people, it could broaden the reach of genetic therapies, which currently have limited clinical applications – partly because there aren’t enough methods for getting those medicines to hone in on the right cells,” writes Cross.
Researchers from MIT and elsewhere have studied the mind of polyglots and uncovered how language-specific regions of the brain respond to different and familiar languages, reports Natalia Mesa for Science. The researchers found that “the activity in the brain’s language network fluctuated based on how well participants understood a language. The more familiar the language, the larger the response,” writes Mesa. “There was one exception to the rule: when participants heard their native tongue, their language networks were actually quieter than when they heard other familiar languages.”
Prof. Evelina Fedorenko speaks with Atlantic reporter Matteo Wong about her research exploring how “the brain behaves when an individual speaks different languages.” Fedorenko explains that “it seems like languages provide us with mappings between forms and meanings.”
MIT scientists have found that silent synapses - a type of memory-forming synapse - are present in the adult brain, reports The Economist. The discovery of these silent synapses, explains Prof. Mark Harnett, “is a lever for us to get into understanding learning in adults and how potentially we can get access to make it not degrade over the course of aging or disease.”
Researchers at MIT have developed new gene-editing technology that can move large sequences of DNA into the human genome, reports Ryan Cross for The Boston Globe. “The molecular tool gives scientists a new way to completely replace broken genes, paving the way to potential cures for diseases such as cystic fibrosis,” writes Cross.
MIT researchers have found that standard autism diagnostic tests could be “stymieing discovery of sex differences in autism,” reports Ingrid Wickelgren for Scientific American. “To qualify for the study, prospective participants had to take a standard activity-based assessment for autism to confirm their diagnosis,” says Wickelgren. “After testing, half of the 50 girls and women who would otherwise be eligible for the scientists’ study did not meet the test’s criteria for autism.”
Researchers from MIT and Boston Children’s Hospital are working on developing new technology that could help predict and identify diseases through audio recordings of a patient’s voice, reports Jim Morelli for Boston 25 News. “It’s almost like being Sherlock Holmes to voice, taking voice as a signal and trying to understand what’s going on behind it,” said Satrajit Ghosh, a principal research scientist at the McGovern Institute. “And can we backtrack from voice and say this is ‘Disorder A’ versus ‘Disorder B’?”
Scientists from MIT, Duke and Stanford have developed a new technique to make gene therapies safer and more effective, reports Ryan Cross for The Boston Globe. “It’s about making these therapies much smarter and programmable,” says Jonathan S. Gootenberg, a research scientist at the McGovern Institute.
Scientists at MIT have found that specific neurons in the human brain light up whenever we see images of food, reports Dr. Mallika Marshall for CBS Boston. “The researchers now want to explore how people’s responses to certain foods might differ depending on their personal preferences, likes and dislikes and past experiences,” Marshall.
MIT researchers have developed a new magnet-based system to monitor muscle movements that could help make prosthetic limbs easier to control, reports Brianna Silva for WHDH.
A study by MIT researchers finds that the screening test used for autism creates a gender gap that impedes diagnosis and treatment for women and girls, reports Sydney Murphy for Health Day. The researchers found that “a screening test often used to decide who can take part in autism studies seems to exclude a much higher percentage of women than men,” writes Murphy.
A new study by MIT researchers finds that women being excluded from studies on autism can hinder diagnoses and the development of useful interventions for women and girls, reports Gianna Melillo for The Hill. “Female diagnoses could be missed altogether and an already small pool of study subjects is further reduced,” writes Melillo.