Professors Edward Boyden and Feng Zhang have been named to the 2018 class of Howard Hughes Medical Institute investigators, reports Jonathan Saltzman for The Boston Globe. “We selected these scientists because they know how to ask hard and interesting questions with skill and intellectual courage,” says David Clapham, vice president and chief scientific officer of the institute.
WBUR’s Maria Garcia explores an exhibit at the MIT Museum of Santiago Ramón y Cajal’s drawings of the human brain. Prof. Robert Desimone, director of the McGovern Institute for Brain Research, explains that, “there's no question that these kinds of circuit diagrams that Cajal was giving us are telling us a great deal about what makes us, us."
“The Beautiful Brain: The Drawings of Santiago Ramón y Cajal” is currently on exhibit at the MIT Museum through the end of 2018. The show features drawings by Cajal that “so effectively illustrate now-basic neurological concepts that they are still used in neuroscience textbooks today,” writes Zoë Schlanger for Quartz.
Researchers at the Broad Institute of MIT and Harvard have programmed CRISPR to “in essence, make edits when significant cellular events occur,” writes Kristin Brown for Gizmodo. “All this adds up to the potential of CRISPR as not just a gene-editing powerhouse, but a multifunctional tool that also works as a biosensor, a medical detective, and an invaluable instrument for basic research.”
A gene-editing tool called SHERLOCK, developed in Prof. Feng Zhang’s lab, allows for faster detection of infections and viruses, such as Zika and Dengue fever. “It does this by combining different types of CRISPR enzymes, which are unleashed together to target distinct bits of DNA and RNA, another of the major biological molecules found in all forms of life,” writes Alessandra Potenza for The Verge.
A study by MIT scientists has identified the neurons that fire at the beginning and end of activities, which is important for initiating a routine. “This task-bracketing appears to be important for initiating a routine and then notifying the brain once it is complete,” Prof. Ann Graybiel told Xinhua.
Boston Herald reporter Lindsay Kalter writes that a team of MIT researchers has developed a new technique that can deliver medication to specific regions of the brain with extreme precision. “The whole idea here is that instead of treating the entire brain, you can treat small portions of the brain,” explains Prof. Michael Cima.
AP reporter Lauran Neergaard writes that MIT researchers have developed a hair-thin implant that can deliver medications to specific regions of the brain. Neergaard writes that the device, “could mark a new approach to treating brain diseases — potentially reducing side effects by targeting only the hard-to-reach circuits that need care.”
Newsweek reporter Joseph Frankel writes that MIT researchers have found that the brain relies on a network of neurons to keep track of time. The researchers found that, “neurons appear to fire in a similar pattern, whether operating at fast or slow speeds...But interestingly, the same patterns stretch or compress over time, depending on the rate of the task.”
MIT researchers have found that a network of neurons compress or stretch their activity in order to control the brain’s timing, reports Alyssa Meyers for The Boston Globe. “Instead of passively waiting for a clock to reach a certain point, the team found the system of neurons changes its state independently based on the action being performed.”
A new study by MIT researchers shows how stress can lead people to make risky decisions, reports Kristin Hugo for Newsweek. “The study lends insights into how neurological disorders affect people. It could be the stress of dealing with inabilities to function properly and staving off cravings, compounded with the chemical effects on the brain, that are influencing people’s uninhibited behavior.”
MIT scientists have developed a technique that could potentially be used one day to treat diseases of the brain, muscles, liver and kidneys by using CRISPR to edit RNA, writes Melissa Healy for The Los Angeles Times. Making edits to the chemical message of RNA, “doesn’t effect a permanent change in a cell’s architectural plan; rather, it essentially alters the implementation of that plan,” explains Healy.
Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”
Prof. Feng Zhang has been awarded the Lemelson-MIT Prize, reports Sharon Begley for STAT. Zhang was honored for his, “track record of innovations and of coming up with big ideas that change fields,” explains Prof. Michael Cima, faculty director of the award. “Zhang is one of those individuals who move through groups of talented people sparking new ideas.”