Koch Institute

MIT researchers have developed a new method to fortify foods and beverages as part of an effort to combat global malnutrition, reports Insha Naureen for Food Ingredients First. “The innovation offers a potential solution to the global malnutrition crisis due to iron deficiency, which can lead to anemia, impaired brain development in children, and increased infant mortality,” Naureen explains. “Beyond iron and iodine, this platform can also deliver multiple micronutrients or bioactive compounds in a single formulation, enabling targeted nutritional strategies,” explains Ana Jaklenec, a principal investigator at the Koch Institute. 

Researchers at MIT have developed a new nutrient fortification process “to deliver essential nutrients such as iron and iodine in foods and drinks,” reports Ben Cornwell for New Food Magazine. “With around two billion people worldwide suffering from iron deficiency, which can lead to anemia, impaired brain development in children and higher infant mortality, this solution from MIT could address a major global issue,” writes Cornwell. 

Researchers at MIT have designed an implantable device that can be used to administer a dose of glucagon to protect Type 1 diabetics from hypoglycemia, reports Amir Khollam. “The device, about the size of a quarter, sits under the skin and releases a dose of glucagon when blood sugar levels dip too low,” explains Khollam. “It can be activated manually or triggered wirelessly by a sensor.” 

Researchers at MIT have developed a new HIV vaccine that could offer “strong protection with just one injection,” reports Ian Randall for Newsweek. “The vaccine includes two ‘adjuvants’—materials that help stimulate the immune system response,” explains Randall. “In the experiments, the dual-adjuvant vaccine was found to produce a wider diversity of antibodies to protect against an HIV protein than with either single adjuvant or none at all.” 

Woods Hole Film Festival will showcase “Cracking the Code: Phil Sharp and the Biotech Revolution,” a film highlighting Prof. Emeritus Phil Sharp’s academic journey and discovery of RNA splicing, reports Erin Trahan for WBUR. The festival runs from July 26 – August 2 in Falmouth, MA. 

Scientific American reporter Nic Flemming spotlights research by Prof. Ömer Yilmaz and his team, which explores the impact of fasting on intestinal stem cells. “Both caloric restriction and fasting improved intestinal stem-cell activity and health, but the mechanisms involved are very different,” says Yilmaz. 

MIT has multiple projects represented in this year’s STAT Madness, a bracket-style competition “highlighting important scientific advances emerging from labs at the nation’s universities, medical schools, and other U.S. research institutions and companies,” reports STAT staff.

MIT Profs. Angela Belcher, Emery Brown, Paula Hammond and Feng Zhang have been honored with National Medals of Science and Technology, reports Michael T. Neitzel for Forbes. Additionally, R. Lawrence Edwards '76 received a National Medal of Science and Noubar Afeyan PhD '87, a member of the MIT Corporation, accepted a National Medal on behalf of Moderna. The recipients have been awarded “the nation’s highest honors for exemplary achievements and leadership in science and technology,” explains Neitzel. 

A new study led by researchers at MIT suggests that fasting and then refeeding stimulates cell regeneration in the intestines, reports Katharine Lang for Medical News Today. However, notes Lang, researchers also found that fasting “carries the risk of stimulating the formation of intestinal tumors.” 

Prof. Ömer Yilmaz and his colleagues have discovered the potential health benefits and consequences of fasting, reports Max Kozlov for Nature. “There is so much emphasis on fasting and how long to be fasting that we’ve kind of overlooked this whole other side of the equation: what is going on in the refed state,” says Yilmaz.

MIT researchers have discovered how fasting impacts the regenerative abilities of intestinal stem cells, reports Ed Cara for Gizmodo. “The major finding of our current study is that refeeding after fasting is a distinct state from fasting itself,” explain Prof. Ömer Yilmaz and postdocs Shinya Imada and Saleh Khawaled. “Post-fasting refeeding augments the ability of intestinal stem cells to, for example, repair the intestine after injury.” 

Prof. Emerita Mary-Lou Pardue, a cellular and molecular biologist whose work “formed the foundation for key advancements and discoveries in understanding the structure of chromosomes,” has died at age 90, reports Bryan Marquard for The Boston Globe. Pardue “was a role model of what women in science can be at a time when there weren’t a lot of those, and a trailblazer as a woman,” emphasizes Ky Lowenhaupt, manager of the Biophysical Instrumentation Facility at MIT, “but also a trailblazer as a scientist who didn’t do things along the path that other people took.”

STAT lists “The Exceptions: Sixteen Women, MIT, and the Fight for Equality in Science,” by Kate Zernicke as a “best book on health and science to check out this summer.”  The book focuses on Prof. Nancy Hopkins’ “career, which culminates in not only numerous scientific successes but also a collaborative effort with 15 other women faculty demonstrating evidence of gender discrimination at MIT,” explains STAT. “This work led to studies to address gender equity at nine other universities.” 

Prof. Sara Seager, Prof. Robert Langer and Prof. Nancy Kanwisher have been awarded the 2024 Kavli Prize for their work in the three award categories: astrophysics, nanoscience, and neuroscience, respectively, reports Michael T. Nietzel for Forbes. According to the Norwegian Academy of Science and Letters, this award honors scientists with outstanding research “that has broadened our understanding of the big, the small and the complex,” writes Nietzel. 

MIT researchers have developed new technology that allows vaccines to be directly inserted into the lymph nodes to target two of the most common mutations in the KRAS gene, which cause roughly one third of all cancers, reports Jaimie Seaton for Scientific American. “The team modified the small vaccine components to include a fatty acid, which enables the vaccine to effectively hitch a ride on albumin, a common protein found throughout the body,” explains Seaton. “Albumin serves as a molecular shuttle bus, with pockets on its surface where fatty acids can bind to it.”