Institute for Medical Engineering and Science (IMES)

Prof. Laura Lewis speaks with New Scientist reporter Grace Wade about the importance of sleep research. Lewis notes that understanding the dynamics of how the brain transitions into sleep could help lead to new treatments for insomnia. “With sleep onset, it has been really difficult for us to find that moment,” says Lewis, where brain mechanisms drive the transition to sleep. “If we knew when that was, then we could start to say, what is the brain region or circuit that is making somebody fall asleep?” 

A new study from researchers at MIT shows that lack of focus after a poor night’s sleep often corresponds with a surge of cerebrospinal fluid in the brain, which usually flows while we’re asleep. “We like to think we’re in control—that willpower, caffeine, and determination can overcome a missed night of sleep,” writes Bill Murphy Jr. for Inc. “However, this research suggests otherwise. When your brain needs to clean itself, it’s going to find a way to do it, whether you’re ready for it or not.”

MIT researchers have developed a new AI tool, dubbed “DrugReflector,” aimed at speeding up the drug discovery process, reports William A. Haseltine for Forbes. The researchers used DrugReflector to test tested almost 9,600 drugs in different human cell types.“This system was 17 times more accurate than older computational methods and improved as it used honest lab feedback,” writes Haseltine. 

Researchers at MIT examined how lack of sleep can impact a person’s attention, and “found that during these moments of brain fog, a wave of cerebrospinal fluid (CSF) is released out of the brain - a process which normally occurs whilst we are sound asleep, and helps to wash away waste products built up during the day,” reports Shaheena Uddin for The Independent. 

Prof. Laura Lewis and her colleagues have discovered that momentary lapses in attention that often follow a bad night’s sleep are caused by the brain attempting to flush fluid out of its system, a process that normally occurs during sleep, reports Carissa Wong for New Scientist. “If you don’t have these waves [of fluid flowing] at night because you’re kept awake all night, then your brain starts to kind of sneak them in during the daytime, but they come with this cost of attention,” says Lewis. 

Researchers at MIT have found that momentary lapses in attention, often described as zoning out, coincide with waves of fluid flowing out of the brain, reports Ian Sample for The Guardian. “The moment somebody’s attention fails is the moment this wave of fluid starts to pulse,” says Prof. Laura Lewis. “It’s not just that your neurons aren’t paying attention to the world, there’s this big change in fluid in the brain at the same time.”

Prof. Alex Shalek and his colleagues developed a deep-learning model called DrugReflector aimed at speeding up the process of drug discovery, reports Heidi Ledford for Nature. “They used DrugReflector to find chemicals that can affect the generation of platelets and red blood cells — a characteristic that could be useful in treating some blood conditions,” explains Ledford. The researchers found that “DrugReflector was up to 17 times more effective at finding relevant compounds than standard, brute-force drug screening that depends on randomly selecting compounds from a chemical library.”

Prof. Laura Lewis speaks with Quanta Magazine reporter Yasemin Saplakoglu about her quest to better understand how the brain transitions to sleep. “Our brains can really rapidly transform us from being aware of our environments to being unconscious, or even experiencing things that aren’t there,” said Lewis. “This raises deeply fascinating questions about our human experience.”

Financial Times reporter Melissa Heikkilä spotlights how MIT researchers have uncovered evidence that increased use of AI tools by medical professionals risks “leading to worse health outcomes for women and ethnic minorities.” One study found that numerous AI models “recommended a much lower level of care for female patients,” writes Heikkilä. “A separate study by the MIT team showed that OpenAI’s GPT-4 and other models also displayed answers that had less compassion towards Black and Asian people seeking support for mental health problems.” 

Prof. Marzyeh Ghassemi speaks with Boston Globe reporter Hiawatha Bray about her work uncovering issues with bias and trustworthiness in medical AI systems. “I love developing AI systems,” says Ghassemi. “I’m a professor at MIT for a reason. But it’s clear to me that naive deployments of these systems, that do not recognize the baggage that human data comes with, will lead to harm.”

Prof. Laura Lewis discusses her research exploring how the flow of cerebrospinal fluid (CSF) in your brain while you sleep can help eliminate “waste," like “excess proteins and other molecules that can be toxic, if not removed,” reports Lydia Denworth for Scientific American. “Lewis found that CSF also flows when people are awake but less effectively,” explains Denworth. “Lewis’s conclusion: sleep, a state that is essential for human health, has a distinct pattern of CSF flow—and that pattern changes as the stages of sleep shift.” 

Using generative AI, researchers at MT have designed new antibiotics to combat MRSA and gonorrhea, reports James Gallagher for the BBC. "We're excited because we show that generative AI can be used to design completely new antibiotics," says Prof. James Collins. "AI can enable us to come up with molecules, cheaply and quickly and in this way, expand our arsenal, and really give us a leg up in the battle of our wits against the genes of superbugs."

Researchers at MIT have designed an implantable device that can be used to administer a dose of glucagon to protect Type 1 diabetics from hypoglycemia, reports Amir Khollam. “The device, about the size of a quarter, sits under the skin and releases a dose of glucagon when blood sugar levels dip too low,” explains Khollam. “It can be activated manually or triggered wirelessly by a sensor.” 

The new Hood Pediatric Innovation Hub, a cornerstone of MIT’s Health and Life Sciences Collaborative (MIT HEALS), is aimed at addressing “underinvestment in pediatric healthcare innovations,” reports Isabel Hart for the Boston Business Journal. Prof. Elazer Edelman, faculty lead for the hub, explains that: “We are trying to build a new culture providing innovation to those who have least access to it and will most benefit from it.”

Prof. David Sontag, Monica Agrawal PhD '23, Luke Murray SM '22, and Divya Gopinath '19, MEng '20 co-founded Layer Health - an AI healthcare startup that is applying large language models (LLMs) to help clinicians with medical chart reviews and data abstraction, reports Seth Joseph for Forbes. “The same chart review problem we’re solving with our clinical registry module is faced by clinicians at the point of care,” says Sontag. “For example, one of our next modules will focus on real-time clinical decision support to help automate clinical care pathways, leading to more reliable, high-quality care."