In a new paper, Prof. Giovanni Traverso and his colleagues highlight the results of a clinical trial that showed “a pill taken just once a week, gradually releasing medicine from within the stomach, can greatly simplify the drug schedule faced by schizophrenia patients,” writes Dennis Thompson for HealthDay News. “These final-stage clinical trial results are the product of more than 10 years of research by Traverso’s lab.”
MIT researchers have developed Boltz-2, an AI algorithm “that unites protein folding and prediction of small-molecule binding affinity in one package,” reports Laura Howes for Chemical & Engineering News. “The researchers say their new AI model approaches the level of accuracy achieved by traditional computational chemistry—such as methods involving free-energy perturbation calculations—but much more quickly and cheaply,” explains Howes.
Researchers at MIT and elsewhere have developed Boltz-2, an open-source generative AI model that can help researchers find new medicines faster, reports Alex Knapp for Forbes. The tool “can not only predict the structure of proteins, it can also predict its binding affinity–that is, how well a potential drug is able to interact with that protein,” explains Knapp. “This is crucial in the early stages of developing a new medicine.”
Graduate students Anika Jane Beamer, Nanticha Ocharoenchai, Pratik Pawar and Paulina Rowińska write for GBH to highlight health care deserts in the Boston area. “There are no hospitals or emergency care facilities in Mattapan,” they write. “With the closure of Carney Hospital, the nearest emergency room is at Brigham and Women’s Faulkner Hospital, over three miles away. Getting there can be difficult.”
Prof. Sebastian Lourido speaks with Salon reporter Elizabeth Hlavinka about the risks associated with parasite cleanses. “When you cause significant changes in the intestine, you are at times obliterating many of the beneficial organisms that are helping us digest food, but in some cases, producing vitamins that are actually occupying that niche and preventing bad organisms from taking over,” says Lourido.
Dr. Mallika Marshall joins CBS Boston to discuss E-BAR, a new mobile robot developed by MIT researchers to physically support the elderly and prevent them from falling as they move around their homes. Marshall notes that E-BAR could also “lift someone from sitting to standing or vice versa, and catch someone safely by rapidly inflating side airbags if they begin to fall.”
Syntis Bio, a biopharmaceutical company co-founded by Prof. Giovanni Traverso and Prof. Robert Langer, is developing a daily obesity pill that mimics the effects of gastric bypass, reports Emily Mullin for Wired. “This material is something you would take as a capsule or liquid, but the next day it's gone because of the natural turnover of our mucosal surface in the GI tract,” says Traverso.
Deborah Blum, director of the Knight Science Journalism Program, writes for The New York Times about the history and future of food safety programs in the U.S. “The United States clearly still needs the safety systems that were so painstakingly built over the last 120 years, and to make them better and stronger,” writes Blum. “The labs and scientists and inspection teams that have been recently lost should not only be restored but expanded. And the mistakes of the 19th century should stay firmly in the history books.”
“AT MIT innovation ranges from awe-inspiring technology to down-to-earth creativity,” notes Chronicle during a visit to campus to peek behind the scenes at the innovations underway at the Institute. Classes taught by Prof. Erik Demaine are a “mix of rigorous math and creative collaboration,” host Anthony Everett explains, highlighting how Demaine’s work in computational origami has found its way into practical applications in such fields as medicine, architecture and space exploration. “I think origami provides a really powerful tool for making transformable shapes,” Demaine relates.
Chronicle visits MIT to learn more about how the Institute “nurtures groundbreaking efforts, reminding us that creativity and science thrive together, inspiring future advancements in engineering, medicine, and beyond.” Prof. Julien de Wit and Research Scientist Artem Burdanov discuss their planetary defense efforts aimed at identifying small asteroids that could pose a threat to Earth, and Prof. Canan Dağdeviren demonstrates her work developing ultrasound devices to detect the earliest stages of breast cancer. Host Anthony Everett notes that: “Big ideas have a way of breaking out of conventional boundaries, just part of what makes MIT one giant laboratory of groundbreaking ideas."
Rachel Feltman of Scientific American’s “Science Quickly” podcast visits MIT.nano to learn more about MIT’s “clean laboratory facility that is critical to nanoscale research, from microelectronics to medical nanotechnology.” Prof. Vladimir Bulović, director of MIT.nano, explains: “Maybe a fifth of all of M.I.T.’s research depends on this facility…from microelectronics to nanotechnology for medicine to different ways of rethinking what will [the] next quantum computation look like. Any of these are really important elements of what we need to discover, but we need all of them to be explored at the nanoscale to get that ultimate performance.”
Prof. Jeffrey Harris speaks with Newsweek reporter Jasmine Laws about how a recession could impact Medicare. "A recession could impact many critical decisions of federal lawmakers, private insurers, healthcare providers, and patients,” says Harris. “The U.S. Congress may decide to let stand the Medicare physician payment cut that became effective on January 1 of this year. Reduced physician payments under conventional Medicare may cause doctors, hospitals and other providers to shift their resources toward the care of younger, commercially insured patients."
Writing for The Boston Globe, Prof. Pierre Azoulay and Prof. Jeffrey Flier of Harvard Medical School make the case that any reforms at the NIH “should be grounded in evidence rather than tradition, avoiding the influence of special interests or political considerations.” They add that this approach “is an acknowledgement of NIH’s accomplishments and a charge to adapt it to the new realities of 21st-century science. The overarching goal must be to secure and enhance the decades-long role of the United States at the forefront of biomedical research, an outcome that the public both wants and deserves.”
MIT has multiple projects represented in this year’s STAT Madness, a bracket-style competition “highlighting important scientific advances emerging from labs at the nation’s universities, medical schools, and other U.S. research institutions and companies,” reports STAT staff.
Evan Ehrenberg PhD '16 co-founded Waterlily, a company that “uses artificial intelligence to predict a family’s future long-term care needs and costs” with the right care and financial planning, reports Mary Ann Azevedo for TechCrunch. “Ehrenberg — who had previously founded and sold Clara Health — helped with early research and was struck by the industry’s response,” writes Azevedo. “Curious, he tested the platform and was shocked by his long-term care predictions — so much so that he changed his diet, hired a personal trainer, and updated his financial plans.”