Work on mapping the human epigenome, led by Professor Manolis Kellis, could reveal the origins of diseases such as cancer and Alzheimer’s, reports Carolyn Johnson for The Boston Globe. “The research was one major piece of a $240 million National Institutes of Health program that funded 88 grants over 10 years,” Johnson explains.
For the first time, researchers have mapped the epigenome, identifying the switches that can turn individual genes on or off, reports Sharon Beagley for Reuters. Says Prof. Manolis Kellis of the need to understand the epigenome, "The only way you can deliver on the promise of precision medicine is by including the epigenome.”
Researchers have mapped the epigenome, shedding light on how genes are controlled, which could be useful in understanding disease, reports Gina Kolata for The New York Times. “We now have an unprecedented view of the living human genome,” says Prof. Manolis Kellis.
WBUR’s Deborah Becker and Lynn Jolicoeur report on the new MIT-MGH partnership aimed at developing better tools to treat disease. Prof. Arup Chakraborty hopes the collaboration will allow researchers to take risks. “Safe ideas are often not the transformative ones,” he says.
Brendan Borrell writes for Scientific American about how MIT researchers have engineered the DNA of E.coli to detect and record environmental information. “Building gene circuits requires not only computation and logic, but a way to store that information,” says Prof. Timothy Lu. “DNA provides a very stable form of memory and will allow us to do more complex computing tasks.”
MIT engineers have altered the DNA of E.coli so that it can store memories, reports Colin Barras for New Scientist. The research could “pave the way for cellular biographers that can be inserted into our bodies for the inside scoop on our health,” Barras explains.
Nature highlights the top science news of the week, including the new interdisciplinary center at MIT aimed at examining the microbiome. “The center will initially focus on inflammatory bowel disease, but organizers hope to eventually broaden the scope to diseases such as multiple sclerosis, arthritis and autism,” Nature reports.
Richard Knox writes for WBUR about Grace Silva, a cancer patient whose tumor was analyzed by a team from MIT and Harvard. The team uncovered genetic mutations in her tumor that allowed them to treat her with a drug matched precisely to her condition, a model for how cancer researchers hope to eventually treat all patients.
Kat McGowan of The Scientific American cites research by Professor Angelica Amon that indicates recent findings may overestimate the amount of genetic variation in healthy human bodies. “Having the wrong chromosome number is not a good thing,” says Amon.
“There are now 108 known places in the genome which point us towards genes that are involved in causation. And, as you suggest, while most are in the nervous system, some of them, very intriguingly, point to the immune system as being involved,” Dr. Steven Hyman says of the new findings on schizophrenia during an interview with the PBS Newshour.
Professor Kenneth Oye speaks with WBUR’s Sacha Pfeiffer about his recent research that details a new way to alter the genomes of organisms and the need for a public discussion about the potential implications and benefits of this new technology.
Los Angeles Times reporter Geoffrey Mohan writes about a new study, coauthored by researchers from the Broad Institute, that identifies over 100 regions in human DNA that correlate with schizophrenia. “The findings provide substantial support for a genetic root to the disorder and greatly narrow the search for genes that may cause the disease, the authors said,” writes Mohan.
In a piece for USA Today, Karen Weintraub reports that scientists have identified more than 100 genes connected to schizophrenia. "Most importantly, the goal is not to end up with a list of genes, but with novel treatments,” explains Steven Hyman, director of the Stanley Center for Psychiatric Research at the Broad Institute.
Associated Press reporter Seth Borenstein writes that researchers have discovered more than 100 spots in our DNA tied to schizophrenia. "It's a genetic revelation; schizophrenia has been a mystery," says study co-author Steve McCarroll, director of genetics for the Broad Institute.
Writing for The New Yorker, Professor Seth Mnookin examines the struggles facing a young couple whose firstborn child was the only known patient with a specific genetic disorder. Mnookin explores how the parents were able to spur research into their son’s disorder by locating other patients with the disease.