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Drug delivery

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Gizmodo

Scientists from MIT and Brigham and Women’s Hospital have developed a plant-based gel that can be used to deliver effective doses of antimicrobial drugs around the world, reports Ed Cara for Gizmodo. The gels “can be produced cheaply and combined with edible materials like beeswax to create different textures and viscosity, ranging from something like a protein shake to yogurt,” writes Cara.

CNET

Researchers at MIT worked with colleagues at Brigham and Women’s Hospital to develop a gel that could deliver drugs that typically come in pill form. “The work involved testing gel formulations with trained food tasters who found that the most appealing versions were made from cottonseed oil (neutral flavor) or sesame oil (nutty flavor),” reports Amanda Kooser for CNET.

FiercePharma

FiercePharma’s Nick Paul Taylor writes about a new drug delivery gel developed by researchers at MIT and Brigham and Women’s Hospital. “Our system is an oil-based system gel, which makes it compatible with most drugs,” says visiting scientist Ameya Kirtane. “This enables the formulation of drugs that were not available in semi-solid or liquid dosage forms and allows patients, especially children, to more easily take their medicine.”

Boston.com

MIT researchers have developed a new drug-delivering gel that could make it easier for children and adults to swallow their medicine, reports Gwen Egan for Boston.com. The gel could be made in a variety of different textures and can be stored without refrigeration.

CBS Boston

Researchers from MIT and Brigham and Women’s Hospital have developed a gel that can be mixed into medicine to make it easier to swallow, reports CBS Boston. “The gel is made out of plant-based oils and doesn’t have to be refrigerated,” says CBS Boston.  “The hope is that it can one day be used to help children and adults who have trouble swallowing pills.”

Forbes

Forbes reporter Jack Kelly profiles Institute Prof. Robert Langer, spotlighting his career journey and his passion for helping others. “I traded job security and high pay for doing things I was passionate about,” Langer explains. “Out of over 20 job offers I received upon graduation from college, I chose the lowest paying one by far because I thought by doing so, I could potentially improve the health of patients. I dreamed about doing things that I thought would make the world a better place.”

La Repubblica

Professor Gio Traverso speaks with Irma D'Aria of La Repubblica about his work on a capsule that can deliver drugs orally that typically need to be injected. “This technological innovation could apply to chronic conditions that require regular dosing of drugs, but also to medical situations that require more sporadic interventions,” said Traverso. “Mass administration of an otherwise injectable drug also becomes much easier if it can be administered orally.”

The Wall Street Journal

In an article for The Wall Street Journal about efforts to help repair or prevent cartilage damage before osteoarthritis sets in, Laura Landro spotlights how MIT researchers are developing “ways to get drugs into the cartilage tissue and keep them there. They are using microscopic particles called nanocarriers to deliver IGF-1, an insulin like growth factor, to the tight mesh that holds cartilage in joints.”

Physics World

MIT researchers have developed a new type of stent based on kirigami, the Japanese art of folding and cutting paper, which is “designed to improve localized drug delivery for diseases that affect tubular organs such as the oesophagus and bowel,” writes Cynthia Keen for Physics World. “We view these approaches as having the capacity to transform the patient experience by reducing the need to take medications and thereby significantly improving drug adherence,” says Prof. Giovanni Traverso.

Medgadget

MIT researchers have developed a new stent based on kirigami, the Japanese art of cutting and folding paper. The stent “can provide localized drug delivery through needle-like projections that pop out when the stent is extended,” reports Conn Hastings for Medgadget.

Stat

A team from MIT has been named a co-winner of this year’s STAT Madness, a bracket-style competition for biomedical research. The team, led by visiting scientist Junwei Li and Prof. Gio Traverso, “developed a solution that, once inside the small intestine, undergoes a reaction and coats it with a temporary adhesive,” which could be used “to make drug delivery more efficient," reports Rebecca Sohn for STAT.

Wired

Prof. Giovanni Traverso has been highlighted by Wired as one of 32 innovators who are changing the world, writes Sanjana Varghese for Wired. Prof. Robert Langer notes that Traverso is “transforming how we interact with medications, for example through the development of pills that remain in the body for multiple weeks or months to address medication non-adherence, or the creation of small, swallowable devices enabling the delivery of biologics like insulin.”

Fast Company

Fast Company reporter Adele Peters spotlights Particles for Humanity, an MIT spinoff that is developing a new technology that makes it possible to deliver multiple doses of a vaccine in one shot. “The new technology works like traditional drug delivery,” writes Peters, “but with the addition of tiny time-release capsules filled with antigens, the part of the vaccine that stimulates the immune system so that it can later respond to a virus.”

Stat

MIT researchers have created a new synthetic lining that could be used to help treat digestive diseases, reports Pratibha Gopalakrishna for STAT. “We wanted to develop a liquid system that is easier to take compared to tablets or capsules, but had enhanced capabilities,” explains Prof. Giovanni Traverso.

New Scientist

New Scientist reporter Alice Klein writes that MIT researchers have developed a synthetic glue that could be used to line the small intestine and help treat several conditions, including diabetes and lactose intolerance. “The researchers found they could control the uptake of different nutrients,” writes Klein, “by adding various substances to the synthetic lining.”