Research affiliate Fei Chen and his colleagues have developed a new method that could be used to uncover the organization and sequence of DNA inside intact cells, reports Nature. The new method could be used to “help to reveal how genome organization changes with disease.”
WBUR’s Carey Goldberg explores how MIT researchers developed a new CRISPR-based research tool that can be used to detect Covid-19. "A lot of things that we try fail," says research scientist Jonathan Gootenberg. "And that’s OK. Because sometimes you find these things that are really, really awesome."
Reporting for WBUR, Carey Goldberg highlights how MIT researchers have developed a new RNA editing tool that could be used to tweak a gene that raises the risk of Alzheimer’s disease. As the effects of RNA editing are not permanent, “it's almost like a small, pill-like version of gene therapy,” explains research scientist and McGovern Fellow Omar Abudayyeh.
Broad Institute postdoctoral associate Joshua Weinstein has developed a DNA microscope that allows researchers to investigate the locations and identity of DNA molecules, reports Sharon Begley for STAT. “Weinstein has so far used it to image human cancer cell lines and plans to apply the technology to tumors and the immune cells that infiltrate them,” writes Begley, “which might one day guide immunotherapy.”
STAT reporter Sharon Begley writes that Prof. Feng Zhang and his colleagues have turned “a jumping gene — aka a transposon, or mobile genetic element — into a mini TaskRabbit gig worker: With an assist from CRISPR enzymes, it zips over to the part of the genome whose address it is given and delivers a package of DNA, pronto.”
MIT researchers developed a new technique to make a more effective and precise CRISPR gene editing system, reports Eileen Drage O’Reilly for Axios. The system uses the new enzyme Cas12b, which has a “small size and precise targeting [that] will enable it to be used for in vivo applications in primary human cells,” O’Reilly explains.
MIT researchers have developed a new app called Perdix that allows users to create 2-D nanostructures using DNA strands, reports Jesus Diaz for Fast Company. Engineers could use Perdix to print nanoscale parts for applications in cell biology, photonics, quantum sensing and computing, Diaz explains.
Boston Globe reporter Martin Finucane writes that MIT researchers have developed a new way to fabricate tiny objects. “The researchers are currently able to create objects that are around 1 cubic millimeter, with features as small as 50 nanometers,” Finucane explains. “The tiny structures could be useful in fields from optics to medicine to robotics.”
MIT researchers have developed a new technique that can shrink objects to the nanoscale using a laser, reports Lauren Kent for CNN. Kent explains that the technology “could be applied to anything from developing smaller microscope and cell phone lenses to creating tiny robots that improve everyday life.”
Popular Mechanics reporter David Grossman writes about a new fabrication technique developed by MIT researchers that allows for regular-sized objects to be shrunk down to the nanoscale. Grossman explains that the new method, “takes a technique currently used to make images of brain tissue larger and reverses it.”
Inside Science reporter Yuen Yiu writes that MIT researchers have developed a new technique for producing nanoscale structures using a 3-D printing method that shrinks objects. Yiu explains that the new technique operates by “first creating a bigger structure inside of a gel, then shrinking the gel, which brings the structure down to one-thousandth the volume of the original.”
MIT researchers have developed a new method to shrink 3-D printed objects, reports Douglas Heaven for New Scientist. The technique can be used to create a wide variety of shapes using different materials. “In the 1970s hobbyists built their own computers at home,” explains Prof. Edward Boyden. “Maybe people can now make their own chips.”
MIT researchers have developed a new technique to measure cancer cells that provides insight into how certain cells respond to treatment, reports the Xinhua news agency. The findings could be used to help develop new drug targets, making current treatments more effective.
Catalog, an MIT startup that creates systems to store data on synthetic DNA molecules, hopes to make a commercial DNA storage product in the next year, reports Hiawatha Bray for The Boston Globe. Using this new form of data storage, “can shrink down entire data centers into shoeboxes of DNA,” says former MIT postdoc and Catalog CEO Hyunjun Park.
Megan Molteni of Wired writes that data storage company, Catalog, an MIT spinout that is working on using DNA to store data. Molteni explains that at Catalog, “they’re building a machine that will write a terabyte of data a day, using 500 trillion molecules of DNA.”